Invention Grant
- Patent Title: Heteroaryl substituted aminopyridine compounds
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Application No.: US15738435Application Date: 2016-06-23
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Publication No.: US10202390B2Publication Date: 2019-02-12
- Inventor: John V. Duncia , Daniel S. Gardner , John Hynes , John E. Macor , Satheesh Kesavan Nair , Venkatram Reddy Paidi , Joseph B. Santella , Kandhasamy Sarkunam , Ramesh Kumar Sistla , Subba Rao Polimera , Hong Wu
- Applicant: BRISTOL-MYERS SQUIBB COMPANY
- Applicant Address: US NJ Princeton
- Assignee: Bristol-Myers Squibb Company
- Current Assignee: Bristol-Myers Squibb Company
- Current Assignee Address: US NJ Princeton
- Agent Gary Greenblatt
- Priority: IN1880/DEL/15 20150624
- International Application: PCT/US2016/038862 WO 20160623
- International Announcement: WO2016/210037 WO 20161229
- Main IPC: C07D487/04
- IPC: C07D487/04

Abstract:
Disclosed are compounds of Formula (I) or salts thereof, wherein: HET is a heteroaryl selected from imidazo[1,2-b]pyridazinyl and pyrazolo[1,5-a]pyrimidinyl, wherein said heteroaryl is attached to the pyridinyl group in the compound of Formula (I) by a carbon ring atom in the heteroaryl and wherein said heteroaryl is substituted with zero to 2 Rb; A is pyrazolyl, imidazolyl, or triazolyl, each substituted with zero or 1 Ra; and R3, Ra, and Rb are define herein. Also disclosed are methods of using such compounds as modulators of IRAK4, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing inflammatory and autoimmune diseases, or in the treatment of cancer.
Public/Granted literature
- US20180179213A1 HETEROARYL SUBSTITUTED AMINOPYRIDINE COMPOUNDS Public/Granted day:2018-06-28
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