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公开(公告)号：US11981680B2
公开(公告)日：2024-05-14
申请号：US17265833
申请日：2019-08-07
IPC分类号： C07D495/04 , A61K45/06 , C07D519/00
CPC分类号： C07D495/04 , A61K45/06 , C07D519/00
摘要： The present invention provides compounds of formula (I) useful as inhibitors of PAD4, compositions thereof, and methods of treating PAD4-related disorders.
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公开(公告)号：US10023562B2
公开(公告)日：2018-07-17
申请号：US15480682
申请日：2017-04-06
发明人： Rajeev S. Bhide , John V. Duncia , John Hynes , Satheesh K. Nair , William J. Pitts , Sreekantha R. Kumar , Daniel S. Gardner , Natesan Murugesan , Venkatram Reddy Paidi , Joseph B. Santella , Ramesh Sistla , Hong Wu
IPC分类号： C07D401/12 , C07D407/14 , C07D405/12 , C07D213/74 , C07D405/14 , C07D401/14 , C07D417/14
摘要： Compounds having the following formula: or a stereoisomer or a pharmaceutically-acceptable salt thereof, wherein R2 is a monocyclic heteroaryl group, and R1, R3, R4, R5 and R6 are as defined herein, are useful as kinase modulators, including IRAK-4 inhibition.
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公开(公告)号：US20170210730A1
公开(公告)日：2017-07-27
申请号：US15480682
申请日：2017-04-06
发明人： Rajeev S. Bhide , John V. Duncia , John Hynes , Satheesh K. Nair , William J. Pitts , Sreekantha R. Kumar , Daniel S. Gardner , Natesan Murugesan , Venkatram Reddy Paidi , Joseph B. Santella , Ramesh Sistla , Hong Wu
IPC分类号： C07D407/14 , C07D213/74 , C07D417/14 , C07D405/14 , C07D401/14 , C07D405/12 , C07D401/12
CPC分类号： C07D407/14 , C07D213/74 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D417/14
摘要： Compounds having the following formula: or a stereoisomer or a pharmaceutically-acceptable salt thereof, wherein R2 is a monocyclic heteroaryl group, and R1, R3, R4, R5 and R6 are as defined herein, are useful as kinase modulators, including IRAK-4 inhibition.
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4.发明授权Bicyclic heterocycle substituted pyridyl compounds useful as kinase modulators 有权用作激酶调节剂的双环杂环取代的吡啶基化合物公开(公告)号：US09546153B2
公开(公告)日：2017-01-17
申请号：US14441698
申请日：2013-11-07
发明人： Rajeev S. Bhide , John V. Duncia , John Hynes , Satheesh K. Nair , William J. Pitts , Sreekantha R. Kumar , Daniel S. Gardner , Natesan Murugesan , Venkatram Reddy Paidi , Joseph B. Santella , Ramesh Sistla , Hong Wu
IPC分类号： C07D401/12 , C07D413/12 , C07D417/12 , C07D487/04 , C07D513/04 , C07D417/14 , C07D471/04
CPC分类号： C07D401/12 , C07D413/12 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/04 , C07D513/04
摘要： Compounds having the following formula (I) or a stereoisomer or a pharmaceutically-acceptable salt thereof, wherein R2 is a bicyclic heterocycle, and R1, R3, R4, R5 and R6 are as defined herein, that are useful as kinase modulators, including IRAK-4 modulation.
摘要翻译： 具有下式（I）的化合物或其立体异构体或其药学上可接受的盐，其中R 2是双环杂环，并且R 1，R 3，R 4，R 5和R 6如本文所定义，其可用作激酶调节剂，包括IRAK -4调制。
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公开(公告)号：US20230203039A1
公开(公告)日：2023-06-29
申请号：US17760309
申请日：2021-02-05
IPC分类号： C07D471/22 , C07D498/22 , C07D487/22 , C07D519/00 , A61K45/06
CPC分类号： C07D471/22 , C07D498/22 , C07D487/22 , C07D519/00 , A61K45/06
摘要： The present invention provides compounds of Formula (I) useful as inhibitors of PAD4, compositions thereof, and methods of treating PAD4-related disorders, (I) wherein ring A, A1, A2, A3, A4, Q, R1, R2, R3, R4, R5, and R6 along with other variables are as defined herein.
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公开(公告)号：US10294229B2
公开(公告)日：2019-05-21
申请号：US15738362
申请日：2016-06-23
发明人： Daniel S. Gardner , Joseph B. Santella , Venkatram Reddy Paidi , Hong Wu , John V. Duncia , Satheesh Kesavan Nair , John Hynes , Xiao Zhu
IPC分类号： A61K31/437 , A61K31/519 , A61P29/00 , C07D487/04 , C07D471/04
摘要： Disclosed are compounds of Formula (I) or salts thereof, wherein HET is a heteroaryl selected from pyrrolo[2,3-b]pyridinyl, pyrrolo[2,3 d]pyrimidinyl, pyrazolo[3,4 b]pyridinyl, pyrazolo[3,4 d]pyrimidinyl, imidazolo[4,5 b]pyridinyl, and imidazolo[4,5 d]pyrimidinyl, wherein said heteroaryl is attached to the pyridinyl group in the compound of Formula (I) by a nitrogen ring atom in said heteroaryl and wherein said heteroaryl is substituted with zero to 2 Rb; A is pyrazolyl, imidazolyl, triazolyl, isoxazolyl, oxadiazolyl or dihydroisoxazolyl, each substituted with zero or 1 Ra; and R3, Ra, and Rb are define herein. Also disclosed are methods of using such compounds as modulators of IRAK4, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing inflammatory and autoimmune diseases, or in the treatment of cancer.
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公开(公告)号：US20150018347A1
公开(公告)日：2015-01-15
申请号：US14503456
申请日：2014-10-01
发明人： T. G. Murali Dhar , John V. Duncia , Daniel S. Gardner , Weiwei Guo , John Hynes
IPC分类号： C07D471/10 , C07D401/12 , C07D405/12 , C07D413/12
CPC分类号： C07D471/10 , A61K31/4427 , C07D401/12 , C07D405/12 , C07D413/12 , C07D471/04
摘要： The present application describes modulators of chemokine receptor activity of formula I or stereoisomers or pharmaceutically acceptable salts thereof. In addition, methods of treating and preventing inflammatory diseases such as asthma and allergic diseases, as well as autoimmune pathologies such as rheumatoid arthritis and transplant rejection using modulators of formula (I) are disclosed.
摘要翻译： 本申请描述了式I的趋化因子受体活性的调节剂或其立体异构体或其药学上可接受的盐。 此外，公开了使用式（I）的调节剂治疗和预防炎性疾病如哮喘和过敏性疾病以及类风湿性关节炎和移植排斥反应的自身免疫病态的方法。
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公开(公告)号：US20220402950A1
公开(公告)日：2022-12-22
申请号：US17265844
申请日：2019-08-07
发明人： Daniel S. Gardner , John V. Duncia , Joseph B. Santella , Khehyong Ngu , Christopher Annunziato
IPC分类号： C07F9/6561 , C07D471/08 , C07D401/14 , A61K45/06
摘要： The present invention provides compounds of Formula (I): useful as inhibitors of PAD4, compositions thereof, and methods of treating PAD4-related disorders.
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公开(公告)号：US20220064180A1
公开(公告)日：2022-03-03
申请号：US17265833
申请日：2019-08-07
IPC分类号： C07D495/04 , A61K45/06 , C07D519/00
摘要： The present invention provides compounds of formula (I) useful as inhibitors of PAD4, compositions thereof, and methods of treating PAD4-related disorders.
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公开(公告)号：US10544133B2
公开(公告)日：2020-01-28
申请号：US16009389
申请日：2018-06-15
发明人： Rajeev S. Bhide , John V. Duncia , John Hynes , Satheesh Kesavan Nair , William J. Pitts , Sreekantha Ratna Kumar , Daniel S. Gardner , Natesan Murugesan , Venkatram Reddy Paidi , Joseph B. Santella , Ramesh Kumar Sistla , Hong Wu
IPC分类号： C07D407/14 , C07D401/14 , C07D401/12 , C07D417/14 , C07D213/74 , C07D405/12 , C07D405/14
摘要： Compounds having the following formula: or a stereoisomer or a pharmaceutically-acceptable salt thereof, wherein R2 is a monocyclic heteroaryl group, and R1, R3, R4, R5 and R6 are as defined herein, are useful as kinase modulators, including IRAK-4 inhibition.
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