A medical connector system including a first connector and a second connector. The first connector has a housing, a biasing member, and at least one projection. The second connector has at least one groove for receiving the at least one projection. The proximal end of the second connector is configured to be at least partially disposed within the distal end of the housing of the first connector. Upon application and release of a first set of opposing axial forces applied to the connector system, the first connector is locked to the second connector and, upon application and release of a second set of opposing axial forces, the first connector is released from the second connector. The connectors may include indicators to show when the connector system is in the locked position.