A system and method for multi-touch integrity sensing for a multi-touch capacitive touch screen determines a distinction between wanted touches, such as via a finger or stylus, and unwanted touches such as via foreign matter, errors, and the like. Mutual capacitance and self-capacitance sensing data is collected and processed to identify reference strengths and detection thresholds. If differences between mutual/self-capacitance strength and the corresponding reference strengths exceed the corresponding detection thresholds, then the touch is classified as an unwanted (for example, water) touch.