Invention Grant
- Patent Title: Factor XIA inhibitors
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Application No.: US15771538Application Date: 2016-10-24
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Publication No.: US10214512B2Publication Date: 2019-02-26
- Inventor: Jiayi Xu , Amjad Ali , Wei Zhou , Ying-Duo Gao , Scott D. Edmondson , Eric Mertz , Santhosh F. Neelamkavil , Weiguo Liu , Wanying Sun , Dong-Ming Shen , Bart Harper , Cheng Zhu , Thomas Bara , Yeon-Hee Lim , Meng Yang
- Applicant: MERCK SHARP & DOHME CORP.
- Applicant Address: US NJ Rahway
- Assignee: Merck Sharp & Dohme Corp.
- Current Assignee: Merck Sharp & Dohme Corp.
- Current Assignee Address: US NJ Rahway
- Agent Nicole M. Beeler; John C. Todaro
- International Application: PCT/US2016/058362 WO 20161024
- International Announcement: WO2017/074832 WO 20170504
- Main IPC: C07D471/08
- IPC: C07D471/08 ; C07D471/18 ; C07D401/14 ; A61P7/02 ; C07D487/08 ; C07D413/14 ; C07D401/04
Abstract:
The present invention provides a compound of Formula (I) and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes. The compounds are selective Factor XIa inhibitors or dual inhibitors of Factor XIa and plasma Kallikrein.
Public/Granted literature
- US20180339977A1 FACTOR XIA INHIBITORS Public/Granted day:2018-11-29
Information query
