In an aspect, a cache memory device receives a request to read an instruction or data associated with a memory device. The request includes a first realm identifier and a realm indicator bit, where the first realm identifier enables identification of a realm that includes one or more selected regions in the memory device. The cache memory device determines whether the first realm identifier matches a second realm identifier in a cache tag when the instruction or data is stored in the cache memory device, where the instruction or data stored in the cache memory device has been decrypted based on an ephemeral encryption key associated with the second realm identifier when the first realm identifier indicates the realm and when the realm indicator bit is enabled. The cache memory device transmits the instruction or data when the first realm identifier matches the second realm identifier.