A dual-domain dynamic multiplexer and a method of transitioning between asynchronous voltage and frequency domains. One embodiment of the dual-domain dynamic multiplexer includes: (1) a first domain having a first voltage and a first clock, and a second domain having a second voltage and a second clock, (2) a plurality of data and data select input pairs wherein a data input of an input pair is in the first domain and a data select input of an input pair is in the second domain, and (3) a pre-charge stage in the second domain that is energized upon an edge of the second clock, whereby one data and data input pair is enabled and data latched in the second domain upon another edge of the second clock.