Invention Grant
- Patent Title: Polypeptides that bind to and inhibit secretion from growth hormone secreting cells
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Application No.: US12996641Application Date: 2009-06-11
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Publication No.: US10240138B2Publication Date: 2019-03-26
- Inventor: Frederic Madec , Phil Lecane , Philip Marks , Keith Foster
- Applicant: Frederic Madec , Phil Lecane , Philip Marks , Keith Foster
- Applicant Address: unknown Abingdon, Oxfordshire
- Assignee: IPSEN BIOINNOVATION LIMITED
- Current Assignee: IPSEN BIOINNOVATION LIMITED
- Current Assignee Address: unknown Abingdon, Oxfordshire
- Agency: Barnes & Thornburg LLP
- Agent Gene J. Yao
- Priority: GB0810782.3 20080612; GB0820965.2 20081117
- International Application: PCT/GB2009/050666 WO 20090611
- International Announcement: WO2009/150470 WO 20091217
- Main IPC: C12N9/50
- IPC: C12N9/50 ; C12N9/64 ; C07K7/08 ; C07K14/33 ; C07K14/48 ; C07K14/575 ; C07K14/60 ; C07K14/65 ; C07K14/82 ; A61K38/00
Abstract:
The present invention relates to a method for suppressing or treating cancer, in particular to a method for suppressing or treating one or more of colorectal cancer, breast cancer, prostate cancer and/or lung cancer. The therapy employs use of a non-cytotoxic protease, which is targeted to a growth hormone-secreting cell such as to a pituitary cell. When so delivered, the protease is internalized and inhibits secretion/transmission of growth hormone from said cell. The present invention also relates to polypeptides and nucleic acids for use in said methods.
Public/Granted literature
- US20110165137A1 SUPPRESSION OF CANCERS Public/Granted day:2011-07-07
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