-
公开(公告)号：US20110165137A1
公开(公告)日：2011-07-07
申请号：US12996641
申请日：2009-06-11
Applicant: Frederic Madec , Phil Lecane , Philip Marks , Keith Foster
Inventor： Frederic Madec , Phil Lecane , Philip Marks , Keith Foster
CPC classification number: C12N9/50 , A61K38/00 , C07K7/086 , C07K14/33 , C07K14/48 , C07K14/575 , C07K14/57563 , C07K14/5759 , C07K14/60 , C07K14/65 , C07K14/82 , C07K2319/035 , C07K2319/06 , C07K2319/33 , C07K2319/50 , C12N9/6489
Abstract: The present invention relates to a method for suppressing or treating cancer, in particular to a method for suppressing or treating one or more of colorectal cancer, breast cancer, prostate cancer and/or lung cancer. The therapy employs use of a non-cytotoxic protease, which is targeted to a growth hormone-secreting cell such as to a pituitary cell. When so delivered, the protease is internalised and inhibits secretion/transmission of growth hormone from said cell. The present invention also relates to polypeptides and nucleic acids for use in said methods.
Abstract translation: 本发明涉及抑制或治疗癌症的方法，特别涉及抑制或治疗结肠直肠癌，乳腺癌，前列腺癌和/或肺癌中的一种或多种的方法。 该疗法使用非细胞毒性蛋白酶，其靶向生长激素分泌细胞，例如垂体细胞。 当这样传递时，蛋白酶被内化并且抑制生长激素从所述细胞的分泌/传递。 本发明还涉及用于所述方法的多肽和核酸。
-
公开(公告)号：US10240138B2
公开(公告)日：2019-03-26
申请号：US12996641
申请日：2009-06-11
Applicant: Frederic Madec , Phil Lecane , Philip Marks , Keith Foster
Inventor： Frederic Madec , Phil Lecane , Philip Marks , Keith Foster
IPC: C12N9/50 , C12N9/64 , C07K7/08 , C07K14/33 , C07K14/48 , C07K14/575 , C07K14/60 , C07K14/65 , C07K14/82 , A61K38/00
Abstract: The present invention relates to a method for suppressing or treating cancer, in particular to a method for suppressing or treating one or more of colorectal cancer, breast cancer, prostate cancer and/or lung cancer. The therapy employs use of a non-cytotoxic protease, which is targeted to a growth hormone-secreting cell such as to a pituitary cell. When so delivered, the protease is internalized and inhibits secretion/transmission of growth hormone from said cell. The present invention also relates to polypeptides and nucleic acids for use in said methods.
-
公开(公告)号：US20110262423A1
公开(公告)日：2011-10-27
申请号：US13125407
申请日：2009-11-17
Applicant: Frederic Madec , Philip Lecane , Philip Mark , Keith Foster
Inventor： Frederic Madec , Philip Lecane , Philip Mark , Keith Foster
CPC classification number: C12N9/50 , A61K38/4893 , A61K47/60 , A61K47/6415 , C07K14/33 , C07K14/4756 , C07K14/485 , C07K14/495 , C07K14/50 , C07K14/503 , C07K14/52 , C07K14/522 , C07K14/5412 , C07K14/65 , C07K14/705 , C07K2319/50 , C07K2319/55 , C07K2319/74 , C12N9/52
Abstract: The present invention relates to polypeptides for use in suppressing cancer and cancer disorders. The treatment employs use of a non-cytotoxic protease, which is targeted to the cancer cell, and, when so delivered, the protease is internalised and inhibits secretion from the cancer cell.
Abstract translation: 本发明涉及用于抑制癌症和癌症疾病的多肽。 该治疗使用靶向癌细胞的非细胞毒性蛋白酶，并且当这样递送时，蛋白酶被内化并且抑制癌细胞的分泌。
-
公开(公告)号：US20110158973A1
公开(公告)日：2011-06-30
申请号：US12969826
申请日：2010-12-16
Applicant: Frederic MADEC , Phil LECANE , Philip MARKS , Keith FOSTER
Inventor： Frederic MADEC , Phil LECANE , Philip MARKS , Keith FOSTER
CPC classification number: C07K14/33 , A61K38/00 , C07K2319/035 , C07K2319/06 , C12N9/50
Abstract: The present invention relates to a method for suppressing or treating cancer, in particular to a method for suppressing or treating one or more of colorectal cancer, breast cancer, prostate cancer and/or lung cancer. The therapy employs use of a non-cytotoxic protease, which is targeted to a growth hormone-secreting cell such as to a pituitary cell. When so delivered, the protease is internalised and inhibits secretion/transmission of growth hormone from said cell. The present invention also relates to polypeptides and nucleic acids for use in said methods.
-
-
-
Search Results
4
records
(took 0.012 seconds)
