Implementations described and claimed herein provide a coordination of interdependent asynchronous reads. In one implementation, an input/output request for a target data block stored on a block device at a virtual address is received. A highest level indirect block from which the target data block depends in a hierarchical data structure pointing to the virtual address of the target data block is identified. The highest level indirect block is uncached. A context item is recorded to an input/output structure for the highest level indirect block. The context item indicates that an ultimate objective of a read request for the highest level indirect block is to retrieve the target data block. The input/output request is asynchronously reissued for the target data block upon receipt of the read request for the highest level indirect block.