A DC and/or an AC power transmission circuit protection system is for protection of a cabling medium. The circuit protection system includes a power supply, a powered device and a circuit protection module that includes an over-current and/or over-voltage circuit module and/or a heat circuit protector. The protection system is disposed between the power supply and the powered device, and interrupts an electrical current that flows through the cabling medium when the over-current and/or over-voltage circuit module and/or the circuit protector exceeds a predetermined level. There is also provided a method to dispose the circuit protection system and the circuit protection module within the circuit and to interrupt the circuit when over-current and/or over-voltage circuit module and/or heat circuit protector exceeds a predetermined level.