发明授权
- 专利标题： Vaccine compositions for porcine epidemic diarrhea virus and porcine deltacoronavirus
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申请号： US15324908申请日： 2015-07-08
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公开(公告)号： US10251950B2公开(公告)日： 2019-04-09
- 发明人: Jacqueline Gayle Marx , John Morgan Hardham , Paul J. Dominowski , Vicki Jon Rapp Gabrielson , Monica Balasch Sanuy , Marta Cabana Sumsi , Laia Plaja Dilmé , Alicia Urniza Hostench , Oscar Romero Galindo
- 申请人： Zoetis Services LLC
- 申请人地址： US NJ Parsippany
- 专利权人： Zoetis Services LLC
- 当前专利权人： Zoetis Services LLC
- 当前专利权人地址： US NJ Parsippany
- 代理商 E. Victor Donahue
- 国际申请： PCT/US2015/039475 WO 20150708
- 国际公布： WO2016/007576 WO 20160114
- 主分类号： A61K39/215
- IPC分类号： A61K39/215 ; C12N7/00 ; A61K39/12 ; A61K39/00
摘要：
The present invention is directed to novel immunogenic compositions that protect swine from disease caused by porcine epidemic diarrhea virus (PEDV). The present invention is also directed to novel immunogenic compositions that protect swine from disease caused by porcine deltacoronavirus (PDCoV), alone or as combination vaccine to protect against PEDV. The compositions of the invention provide killed viruses whose effectiveness is enhanced by the selection of preferred adjuvants. Novel culture methods are also employed to increase reproducible yield of cultured viruses. Live vaccines are also provided from the Calaf14 PEDV isolate.
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