公开(公告)号：US20240226270A1

公开(公告)日：2024-07-11

申请号：US17177724

申请日：2021-02-17

申请人： Zoetis Services LLC

发明人： Jacqueline Gayle Marx ,  John Morgan Hardham ,  Paul J. Dominowski ,  Vicki Jon Rapp Gabrielson ,  Monica Balasch Sanuy ,  Marta Cabana Sumsi ,  Laia PIaja Dilmé ,  Alicia URNIZA Hostench ,  Oscar Romero Galindo

IPC分类号： A61K39/215 ,  A61K39/00 ,  A61K39/12 ,  C12N7/00

CPC分类号： A61K39/215 ,  A61K39/12 ,  C12N7/00 ,  A61K2039/5252 ,  A61K2039/552 ,  A61K2039/55505 ,  A61K2039/55566 ,  A61K2039/575 ,  A61K2039/70 ,  C12N2770/20022 ,  C12N2770/20034 ,  C12N2770/20063 ,  C12N2770/20071

摘要： The present invention is directed to novel immunogenic compositions that protect swine from disease caused by porcine epidemic diarrhea virus (PEDV). The present invention is also directed to novel immunogenic compositions that protect swine from disease caused by porcine deltacoronavirus (PDCoV), alone or as combination vaccine to protect against PEDV. The compositions of the invention provide killed viruses whose effectiveness is enhanced by the selection of preferred adjuvants. Novel culture methods are also employed to increase reproducible yield of cultured viruses. Live vaccines are also provided from the Calaf14 PEDV isolate.

公开(公告)号：US10953088B2

公开(公告)日：2021-03-23

申请号：US16282953

申请日：2019-02-22

申请人： Zoetis Services LLC

发明人： Jacqueline Gayle Marx ,  John Morgan Hardham ,  Paul J. Dominowski ,  Vicki Jon Rapp Gabrielson ,  Monica Balasch Sanuy ,  Marta Cabana Sumsi ,  Laia Plaja Dilme ,  Alicia Urniza Hostench ,  Oscar Romero Galindo

IPC分类号： A61K39/215 ,  C12N7/00 ,  A61K39/12 ,  A61K39/00

摘要： The present invention is directed to novel immunogenic compositions that protect swine from disease caused by porcine epidemic diarrhea virus (PEDV). The present invention is also directed to novel immunogenic compositions that protect swine from disease caused by porcine deltacoronavirus (PDCoV), alone or as combination vaccine to protect against PEDV. The compositions of the invention provide killed viruses whose effectiveness is enhanced by the selection of preferred adjuvants. Novel culture methods are also employed to increase reproducible yield of cultured viruses. Live vaccines are also provided from the Calaf14 PEDV isolate.

公开(公告)号：US20190216919A1

公开(公告)日：2019-07-18

申请号：US16282953

申请日：2019-02-22

申请人： Zoetis Services LLC

发明人： Jacqueline Gayle Marx ,  John Morgan Hardham ,  Paul J. Dominowski ,  Vicki Jon Rapp Gabrielson ,  Monica Balasch Sanuy ,  Marta Cabana Sumsi ,  Laia Plaja Dilme ,  Alicia Urniza Hostench ,  Oscar Romero Galindo

IPC分类号： A61K39/215 ,  C12N7/00 ,  A61K39/12

CPC分类号： A61K39/215 ,  A61K39/12 ,  A61K2039/5252 ,  A61K2039/552 ,  A61K2039/55505 ,  A61K2039/55566 ,  A61K2039/575 ,  A61K2039/70 ,  C12N7/00 ,  C12N2770/20022 ,  C12N2770/20034 ,  C12N2770/20063 ,  C12N2770/20071

摘要： The present invention is directed to novel immunogenic compositions that protect swine from disease caused by porcine epidemic diarrhea virus (PEDV). The present invention is also directed to novel immunogenic compositions that protect swine from disease caused by porcine deltacoronavirus (PDCoV), alone or as combination vaccine to protect against PEDV. The compositions of the invention provide killed viruses whose effectiveness is enhanced by the selection of preferred adjuvants. Novel culture methods are also employed to increase reproducible yield of cultured viruses. Live vaccines are also provided from the Calaf14 PEDV isolate.

公开(公告)号：US20170202951A1

公开(公告)日：2017-07-20

申请号：US15324908

申请日：2015-07-08

申请人： Zoetis Services LLC

发明人： Jacqueline Gayle MARX ,  John Morgan Hardham ,  Paul J. Dominowski ,  Vicki Jon Rielson ,  Monica Sanuy Balasch ,  Marta Cabana Sumsi ,  Laia Plaja Dilmé ,  Alicia URNIZA Hostench ,  Oscar Romero Galindo

IPC分类号： A61K39/215 ,  C12N7/00

CPC分类号： A61K39/215 ,  A61K39/12 ,  A61K2039/5252 ,  A61K2039/552 ,  A61K2039/55505 ,  A61K2039/55566 ,  A61K2039/575 ,  A61K2039/70 ,  C12N7/00 ,  C12N2770/20022 ,  C12N2770/20034 ,  C12N2770/20063 ,  C12N2770/20071

摘要： The present invention is directed to novel immunogenic compositions that protect swine from disease caused by porcine epidemic diarrhea virus (PEDV). The present invention is also directed to novel immunogenic compositions that protect swine from disease caused by porcine deltacoronavirus (PDCoV), alone or as combination vaccine to protect against PEDV. The compositions of the invention provide killed viruses whose effectiveness is enhanced by the selection of preferred adjuvants. Novel culture methods are also employed to increase reproducible yield of cultured viruses. Live vaccines are also provided from the Calaf14 PEDV isolate.

公开(公告)号：US10251950B2

公开(公告)日：2019-04-09

申请号：US15324908

申请日：2015-07-08

申请人： Zoetis Services LLC

发明人： Jacqueline Gayle Marx ,  John Morgan Hardham ,  Paul J. Dominowski ,  Vicki Jon Rapp Gabrielson ,  Monica Balasch Sanuy ,  Marta Cabana Sumsi ,  Laia Plaja Dilmé ,  Alicia Urniza Hostench ,  Oscar Romero Galindo

IPC分类号： A61K39/215 ,  C12N7/00 ,  A61K39/12 ,  A61K39/00

摘要： The present invention is directed to novel immunogenic compositions that protect swine from disease caused by porcine epidemic diarrhea virus (PEDV). The present invention is also directed to novel immunogenic compositions that protect swine from disease caused by porcine deltacoronavirus (PDCoV), alone or as combination vaccine to protect against PEDV. The compositions of the invention provide killed viruses whose effectiveness is enhanced by the selection of preferred adjuvants. Novel culture methods are also employed to increase reproducible yield of cultured viruses. Live vaccines are also provided from the Calaf14 PEDV isolate.