发明授权
- 专利标题： Chemical reprogramming of human glial cells into neurons with small molecule cocktail
-
申请号： US15828652申请日： 2017-12-01
-
公开(公告)号： US10253293B2公开(公告)日： 2019-04-09
- 发明人: Gong Chen , Lei Zhang , Jiuchao Yin , Ningxin Ma
- 申请人： The Penn State Research Foundation
- 申请人地址： US PA University Park
- 专利权人： The Penn State Research Foundation
- 当前专利权人： The Penn State Research Foundation
- 当前专利权人地址： US PA University Park
- 代理机构： Hodgson Russ LLP
- 主分类号： A61K33/14
- IPC分类号： A61K33/14 ; A61K31/192 ; A61K31/375 ; A61K31/506 ; A61K31/4418 ; A61K31/4545 ; C12N5/0793
摘要：
Provided are compositions, articles and methods that relate to promoting neurogenesis or neuroregeneration in mammalian nervous system. Embodiments relate to use of groups of compounds that contain Crizotinib (Cri), Flurbiprofen, Lithium Chloride (Li), Vitamin C (VC), Ceritinib (Cer) or Pirfenidone (PFD). In certain implementations glial cells are converted into functional neurons.
公开/授权文献
信息查询
