-
公开(公告)号：US09885015B2
公开(公告)日：2018-02-06
申请号：US15367382
申请日：2016-12-02
发明人： Gong Chen , Lei Zhang , Jiuchao Yin , Ningxin Ma
IPC分类号： A61K31/192 , A61K31/175 , A61K31/4418 , A61K31/4545 , A61K31/506 , A61K33/14 , C12N5/0793 , A61K31/375
CPC分类号： C12N5/0619 , A61K31/192 , A61K31/375 , A61K31/4418 , A61K31/4545 , A61K31/506 , A61K33/14 , C12N2506/08 , A61K2300/00
摘要： Provided are compositions, articles and methods that relate to promoting neurogenesis or neuroregeneration in mammalian nervous system. Embodiments relate to use of groups of compounds that contain Crizotinib (Cri), Flurbiprofen, Lithium Chloride (Li), Vitamin C (VC), Ceritinib (Cer) or Pirfenidone (PFD). In certain implementations glial cells are converted into functional neurons.
-
2.发明授权公开(公告)号：US11116815B2
公开(公告)日：2021-09-14
申请号：US16588054
申请日：2019-09-30
发明人： Gong Chen , Gang-Yi Wu , Lei Zhang , Jiu-Chao Yin , Hana Yeh , Ning-Xin Ma , Grace Lee
IPC分类号： A61K31/519 , A61K31/4439 , A61K31/506 , A61K31/00 , A61K38/05 , C12N5/0793
摘要： Provided are methods and compositions from reprogramming human glial cells into human neurons. The reprogramming is achieved using combinations of compounds that can modify signaling via Transforming growth factor beta (TGF-β), Bone morphogenetic protein (BMP), glycogen synthase kinase 3 (GSK-3), and γ-secretase/Notch pathways. The reprogramming is demonstrated using groups of three or four compounds that are chosen from the group thiazovivin, LDN193189, SB431542, TTNPB, CHIR99021, DAPT, VPA, SAG purmorphamine. Reprogramming is demonstrated using the group of LDN193189/CHIR99021/DAPT, the group of B431542/CHIR99021/DAPT, the group of LDN193189/DAPT/SB431542, the group of LDN193189/CHIR99021/SB431542, a three drug combination of SB431542/CHIR99021/DAPT. Reprogramming using functional analogs of the compounds is also provided, as are pharmaceutical formulations that contain the drug combinations.
-
公开(公告)号：US10311992B2
公开(公告)日：2019-06-04
申请号：US14815546
申请日：2015-07-31
发明人： Roman Engel-Herbert , Lei Zhang
摘要： Transparent conducting films including an alkaline earth, transition metal oxide and their optimization of electrical conductivity and optical transparency by aliovalent substitution, which are useful as electrodes for semiconductors and other electronic devices are disclosed. Such materials include thin films of an aliovalent substituted transition metal oxides of Formula (I): A1-xA′xB1-yB′yO3-d (I) or a transition metal oxide of Formula (II): (ABO3-d)m(A′B′O3-d′)n.
-
4.发明授权公开(公告)号：US09717804B2
公开(公告)日：2017-08-01
申请号：US14438765
申请日：2013-07-19
发明人： Gong Chen , Lei Zhang , Zheng Wu , Yuchen Chen , Fan Wang , Ziyuan Guo
CPC分类号： A61K48/005 , A01K2227/105 , A01K2267/0356 , A61K38/1709 , C12N15/86 , C12N2740/13043
摘要： Methods for producing new neurons in the brain in vivo are provided according to aspects of the present invention which include introducing NeuroD1 into a glial cell, particularly into a reactive astrocyte or NG2 cell, thereby “converting” the reactive glial cell to a neuron. Methods of producing a neuronal phenotype in a glial cell are provided according to aspects of the present invention which include expressing exogenous NeuroD1 in the glial cell, wherein expressing exogenous NeuroD1 includes delivering an expression vector, such as a viral expression vector, including a nucleic acid encoding the exogenous NeuroD1 to the glial cell.
-
5.发明申请REGENERATING FUNCTIONAL NEURONS FOR TREATMENT OF DISEASE AND INJURY IN THE NERVOUS SYSTEM 有权恢复神经系统治疗疾病和伤害的功能神经元公开(公告)号：US20150250900A1
公开(公告)日：2015-09-10
申请号：US14438765
申请日：2013-07-19
发明人： Gong Chen , Lei Zhang , Zheng Wu , Yuchen Chen , Fan Wang , Ziyuan Guo
CPC分类号： A61K48/005 , A01K2227/105 , A01K2267/0356 , A61K38/1709 , C12N15/86 , C12N2740/13043
摘要： Methods for producing new neurons in the brain in vivo are provided according to aspects of the present invention which include introducing NeuroD1 into a glial cell, particularly into a reactive astrocyte or NG2 cell, thereby “converting” the reactive glial cell to a neuron. Methods of producing a neuronal phenotype in a glial cell are provided according to aspects of the present invention which include expressing exogenous NeuroD1 in the glial cell, wherein expressing exogenous NeuroD1 includes delivering an expression vector, such as a viral expression vector, including a nucleic acid encoding the exogenous NeuroD1 to the glial cell.
摘要翻译： 根据本发明的方面提供了在体内产生脑中新神经元的方法，其包括将NeuroD1引入神经胶质细胞，特别是引入反应性星形胶质细胞或NG2细胞，由此将反应性胶质细胞转化为神经元。 根据本发明的方面提供神经元表型的方法，其包括在神经胶质细胞中表达外源性NeuroD1，其中表达外源性NeuroD1包括递送表达载体，如病毒表达载体，包括核酸 编码外源性NeuroD1到胶质细胞。
-
公开(公告)号：US11167044B2
公开(公告)日：2021-11-09
申请号：US16230364
申请日：2018-12-21
发明人： Gong Chen , Lei Zhang , Zheng Wu , Yuchen Chen , Fan Wang , Ziyuan Guo
摘要： Methods for producing new neurons in the brain in vivo are provided according to aspects of the present invention which include introducing NeuroD1 into a glial cell, particularly into a reactive astrocyte or NG2 cell, thereby “converting” the reactive glial cell to a neuron. Methods of producing a neuronal phenotype in a glial cell are provided according to aspects of the present invention which include expressing exogenous NeuroD1 in the glial cell, wherein expressing exogenous NeuroD1 includes delivering an expression vector, such as a viral expression vector, including a nucleic acid encoding the exogenous NeuroD1 to the glial cell.
-
7.发明授权公开(公告)号：US11850273B2
公开(公告)日：2023-12-26
申请号：US17397927
申请日：2021-08-09
发明人： Gong Chen , Gang-Yi Wu , Lei Zhang , Jiu-Chao Yin , Hana Yeh , Ning-Xin Ma , Grace Lee
IPC分类号： A61K38/05 , A61K31/519 , A61K31/4439 , A61K31/506 , A61K31/00 , C12N5/0793
CPC分类号： A61K38/05 , A61K31/00 , A61K31/4439 , A61K31/506 , A61K31/519 , C12N5/0619 , C12N2501/15 , C12N2501/155 , C12N2501/727 , C12N2501/998 , C12N2501/999 , C12N2506/08 , A61K31/4439 , A61K2300/00 , A61K31/519 , A61K2300/00 , A61K31/506 , A61K2300/00
摘要： Provided are methods and compositions from reprogramming human glial cells into human neurons. The reprogramming is achieved using combinations of compounds that can modify signaling via Transforming growth factor beta (TGF-β), Bone morphogenetic protein (BMP), glycogen synthase kinase 3 (GSK-3), and γ-secretase/Notch pathways. The reprogramming is demonstrated using groups of three or four compounds that are chosen from the group thiazovivin, LDN193189, SB431542, TTNPB, CHIR99021, DAPT, VPA, SAG; purmorphamine. Reprogramming is demonstrated using the group of LDN193189/CHIR99021/DAPT, the group of B431542/CHIR99021/DAPT, the group of LDN193189/DAPT/SB431542, the group of LDN193189/CHIR99021/SB431542, a three drug combination of SB431542/CHIR99021/DAPT. Reprogramming using functional analogs of the compounds is also provided, as are pharmaceutical formulations that contain the drug combinations.
-
公开(公告)号：US20210032300A1
公开(公告)日：2021-02-04
申请号：US16966691
申请日：2019-02-01
发明人： Gong Chen , Lei Zhang , Ziyuan Guo , Zifei Pei
摘要： This document provides methods and materials for treating brain injuries. For example, methods and materials for using nucleic acid encoding a NeuroD1 polypeptide to convert reactive astrocytes within a brain (e.g., cerebral cortex) into functional neurons (e.g., neurons that can be functionally integrated into the brain of a living mammal (e.g., a human)) are provided.
-
9.发明申请公开(公告)号：US20190117797A1
公开(公告)日：2019-04-25
申请号：US16230364
申请日：2018-12-21
发明人： Gong Chen , Lei Zhang , Zheng Wu , Yuchen Chen , Fan Wang , Ziyuan Guo
摘要： Methods for producing new neurons in the brain in vivo are provided according to aspects of the present invention which include introducing NeuroD1 into a glial cell, particularly into a reactive astrocyte or NG2 cell, thereby “converting” the reactive glial cell to a neuron. Methods of producing a neuronal phenotype in a glial cell are provided according to aspects of the present invention which include expressing exogenous NeuroD1 in the glial cell, wherein expressing exogenous NeuroD1 includes delivering an expression vector, such as a viral expression vector, including a nucleic acid encoding the exogenous NeuroD1 to the glial cell.
-
10.发明授权公开(公告)号：US10201619B2
公开(公告)日：2019-02-12
申请号：US15643186
申请日：2017-07-06
发明人： Gong Chen , Lei Zhang , Zheng Wu , Yuchen Chen , Fan Wang , Ziyuan Guo
摘要： Methods for producing new neurons in the brain in vivo are provided according to aspects of the present invention which include introducing NeuroD1 into a glial cell, particularly into a reactive astrocyte or NG2 cell, thereby “converting” the reactive glial cell to a neuron. Methods of producing a neuronal phenotype in a glial cell are provided according to aspects of the present invention which include expressing exogenous NeuroD1 in the glial cell, wherein expressing exogenous NeuroD1 includes delivering an expression vector, such as a viral expression vector, including a nucleic acid encoding the exogenous NeuroD1 to the glial cell.
-
-
-
-
-
-
-
-
-
搜索结果
16 条记录 (耗时 0.025 秒)
