Methods, systems, and computer-readable media are disclosed for compression of sequencing data. One method includes receiving waveform data associated with a chemical event occurring on a sensor array, the waveform data including a plurality of time-based waveforms of a corresponding plurality of locations of the sensor array; converting, by at least one processor, each time-based waveform of the waveform data into a frequency-domain spectrum; generating, by the at least one processor, a key frame based on a plurality of the frequency-domain spectrums; calculating, by the at least one processor, for each of the frequency-domain spectrums, a difference between the frequency-domain spectrum and the key frame; and encoding, by the at least one processor, each calculated difference between the frequency-domain spectrum and the key frame.