公开(公告)号：US12241121B2

公开(公告)日：2025-03-04

申请号：US15929970

申请日：2020-06-01

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Benjamin Donnet

IPC: C12Q1/6869 ,  G16B25/00

Abstract: Embodiments disclose methods, systems, and computer-readable media for accelerated base calling of sequencing data. These methods may be adapted to accelerate sequence determination for data arising from a variety of different nucleic acid sequencing platforms. In various embodiments, configurable logic circuits such as FPGAs and GPUs may be adapted to perform raw signal processing, basecalling, and/or sequence determination operations providing further enhancements to the sequence analysis methods.

公开(公告)号：US10676787B2

公开(公告)日：2020-06-09

申请号：US14880439

申请日：2015-10-12

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Benjamin Donnet

IPC: C12Q1/6869 ,  G16B25/00

Abstract: Embodiments disclose methods, systems, and computer-readable media for accelerated base calling of sequencing data. These methods may be adapted to accelerate sequence determination for data arising from a variety of different nucleic acid sequencing platforms. In various embodiments, configurable logic circuits such as FPGAs and GPUs may be adapted to perform raw signal processing, basecalling, and/or sequence determination operations providing further enhancements to the sequence analysis methods.

公开(公告)号：US10254242B2

公开(公告)日：2019-04-09

申请号：US14729640

申请日：2015-06-03

Applicant: Life Technologies Corporation

Inventor： Benjamin Donnet

IPC: G01N27/414

Abstract: Methods, systems, and computer-readable media are disclosed for compression of sequencing data. One method includes receiving waveform data associated with a chemical event occurring on a sensor array, the waveform data including a plurality of time-based waveforms of a corresponding plurality of locations of the sensor array; converting, by at least one processor, each time-based waveform of the waveform data into a frequency-domain spectrum; generating, by the at least one processor, a key frame based on a plurality of the frequency-domain spectrums; calculating, by the at least one processor, for each of the frequency-domain spectrums, a difference between the frequency-domain spectrum and the key frame; and encoding, by the at least one processor, each calculated difference between the frequency-domain spectrum and the key frame.