Embodiments of full-duplex self-interference cancellation systems are described. In one embodiment, a full-duplex transceiver includes a digital signal processor that processes digital signals, a transmit chain that receives a first digital baseband signal from the digital signal processor and converts it to a first RF signal, a receive chain that receives a second RF signal and converts the second RF signal to a second digital baseband signal, and an auxiliary receive chain that receives a portion of the first RF signal and converts it to an auxiliary digital baseband signal. The transceiver may further include a self-interference canceller that applies a channel transfer function to the auxiliary digital baseband signal to generate a cancellation signal and subtracts the cancellation signal from the second digital baseband signal to cancel self-interference at the transceiver. The suppression of self-interference in the transceiver assists the transceiver to achieve higher efficiency in full-duplex communications.