Invention Grant
- Patent Title: Formulation and delivery of modified nucleoside, nucleotide, and nucleic acid compositions
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Application No.: US14775773Application Date: 2014-03-14
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Publication No.: US10258698B2Publication Date: 2019-04-16
- Inventor: Stephen G. Hoge , Örn Almarsson , David D. Hile , Ciarán Lawlor , John Podobinski , Staci Sabnis , Antonin de Fougerolles , Divakar Ramakrishnan , Kristy M. Wood
- Applicant: ModernaTX, Inc.
- Applicant Address: US MA Cambridge
- Assignee: ModernaTX, Inc.
- Current Assignee: ModernaTX, Inc.
- Current Assignee Address: US MA Cambridge
- Agency: Clark & Elbing LLP
- International Application: PCT/US2014/027077 WO 20140314
- International Announcement: WO2014/152211 WO 20140925
- Main IPC: A61K48/00
- IPC: A61K48/00 ; A61K31/7105 ; C12Q1/68 ; C12N15/87 ; C12N15/88 ; A61K47/52
Abstract:
The present disclosure provides, inter alia, formulation compositions comprising modified nucleic acid molecules which may encode a protein, a protein precursor, or a partially or fully processed form of the protein or a protein precursor. The formulation composition may further include a modified nucleic acid molecule and a delivery agent. The present invention further provides nucleic acids useful for encoding polypeptides capable of modulating a cell's function and/or activity.
Public/Granted literature
- US20160038612A1 FORMULATION AND DELIVERY OF MODIFIED NUCLEOSIDE, NUCLEOTIDE, AND NUCLEIC ACID COMPOSITIONS Public/Granted day:2016-02-11
Information query
