公开(公告)号：US20170130255A1

公开(公告)日：2017-05-11

申请号：US15356132

申请日：2016-11-18

Applicant: ModernaTX, Inc.

Inventor： Yuxun Wang ,  Divakar Ramakrishnan ,  Antonin De Fougerolles ,  Susan Whoriskey

IPC: C12P19/34 ,  C12N9/12

CPC classification number: C12P19/34 ,  C12N9/1241 ,  C12N9/1247 ,  C12N9/1252 ,  C12Y207/07006 ,  C12Y207/07007 ,  C12Y207/0705

Abstract: The invention relates to compositions and methods for the design, evolution, preparation, and/or manufacture of enzymes for use with polynucleotides, primary transcripts and mmRNA molecules.

公开(公告)号：US09512456B2

公开(公告)日：2016-12-06

申请号：US14421291

申请日：2013-08-13

Applicant: ModernaTX, Inc.

Inventor： Yuxun Wang ,  Divakar Ramakrishnan ,  Antonin de Fougerolles ,  Susan Whoriskey

IPC: C12P19/34 ,  C12N9/12

CPC classification number: C12P19/34 ,  C12N9/1241 ,  C12N9/1247 ,  C12N9/1252 ,  C12Y207/07006 ,  C12Y207/07007 ,  C12Y207/0705

Abstract: The invention relates to compositions and methods for the design, evolution, preparation, and/or manufacture of enzymes for use with polynucleotides, primary transcripts and mmRNA molecules.

Abstract translation: 本发明涉及用于与多核苷酸，初级转录物和mmRNA分子一起使用的酶的设计，进化，制备和/或制备的组合物和方法。

公开(公告)号：US10258698B2

公开(公告)日：2019-04-16

申请号：US14775773

申请日：2014-03-14

Applicant: ModernaTX, Inc.

Inventor： Stephen G. Hoge ,  Örn Almarsson ,  David D. Hile ,  Ciarán Lawlor ,  John Podobinski ,  Staci Sabnis ,  Antonin de Fougerolles ,  Divakar Ramakrishnan ,  Kristy M. Wood

IPC: A61K48/00 ,  A61K31/7105 ,  C12Q1/68 ,  C12N15/87 ,  C12N15/88 ,  A61K47/52

Abstract: The present disclosure provides, inter alia, formulation compositions comprising modified nucleic acid molecules which may encode a protein, a protein precursor, or a partially or fully processed form of the protein or a protein precursor. The formulation composition may further include a modified nucleic acid molecule and a delivery agent. The present invention further provides nucleic acids useful for encoding polypeptides capable of modulating a cell's function and/or activity.

公开(公告)号：US09790531B2

公开(公告)日：2017-10-17

申请号：US15356132

申请日：2016-11-18

Applicant: ModernaTX, Inc.

Inventor： Yuxun Wang ,  Divakar Ramakrishnan ,  Antonin De Fougerolles ,  Susan Whoriskey

IPC: C12P19/34 ,  C12N9/12 ,  C12N15/52 ,  C12N15/54 ,  C12N15/63 ,  C12N15/70

CPC classification number: C12P19/34 ,  C12N9/1241 ,  C12N9/1247 ,  C12N9/1252 ,  C12Y207/07006 ,  C12Y207/07007 ,  C12Y207/0705

Abstract: The invention relates to compositions and methods for the design, evolution, preparation, and/or manufacture of enzymes for use with polynucleotides, primary transcripts and mmRNA molecules.

公开(公告)号：US20190142971A1

公开(公告)日：2019-05-16

申请号：US16050845

申请日：2018-07-31

Applicant: ModernaTX, Inc.

Inventor： Stephen G. Hoge ,  Örn Almarsson ,  David D. Hile ,  Ciáran Lawlor ,  John Podobinski ,  Staci Sabnis ,  Antonin De Fougerolles ,  Divakar Ramakrishnan ,  Kristy M. Wood

IPC: A61K48/00 ,  A61K47/52 ,  C12N15/88 ,  C12N15/87

Abstract: The present disclosure provides, inter alia, formulation compositions comprising modified nucleic acid molecules which may encode a protein, a protein precursor, or a partially or fully processed form of the protein or a protein precursor. The formulation composition may further include a modified nucleic acid molecule and a delivery agent. The present invention further provides nucleic acids useful for encoding polypeptides capable of modulating a cell's function and/or activity.