An amplifier system includes a main amplifier, a cross-over current detector and a controller. The main amplifier includes at least a first driving transistor and a second driving transistor serving as a differential pair, wherein the first driving transistor and the second driving transistor are arranged to receive a first input signal and a second input signal, respectively. The cross-over current detector is coupled to the main amplifier, and is arranged for detecting a cross-over current of the main amplifier, wherein the cross-over current of the main amplifier is an overlapped current from the differential pair. The controller is coupled to the main amplifier and the cross-over current detector, and is arranged for generating a control signal to control a gain of the main amplifier according to an output of the main amplifier and the cross-over current of the main amplifier.