Invention Grant
- Patent Title: Modified relaxin polypeptides comprising a pharmacokinetic enhancer and uses thereof
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Application No.: US15891492Application Date: 2018-02-08
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Publication No.: US10266578B2Publication Date: 2019-04-23
- Inventor: Gene M. Dubowchik , Olafur S. Gudmundsson , Xiaojun Han , R. Michael Lawrence , Dasa Lipovsek , Cort S. Madsen , Claudio Mapelli , Paul E. Morin , Michael C. Myers
- Applicant: BRISTOL-MYERS SQUIBB COMPANY
- Applicant Address: US NJ Princeton
- Assignee: Bristol-Myers Squibb Company
- Current Assignee: Bristol-Myers Squibb Company
- Current Assignee Address: US NJ Princeton
- Agency: LeClairRyan PLLC
- Agent Robin L. Teskin
- Main IPC: A61K38/18
- IPC: A61K38/18 ; C07K14/64 ; C07K1/107 ; A61K38/00 ; A61K47/64 ; A61P9/00 ; A61K45/06
Abstract:
The present disclosure generally relates to modified relaxin polypeptides, such as modified human relaxin 2 polypeptides, comprising a non-naturally encoded amino acid which is linked to a pharmacokinetic enhancer, and therapeutic uses of such polypeptides, such as for the treatment of cardiovascular conditions (such as heart failure) and/or conditions relating to fibrosis.
Public/Granted literature
- US20180222960A1 MODIFIED RELAXIN POLYPEPTIDES COMPRISING A PHARMACOKINETIC ENHANCER AND USES THEREOF Public/Granted day:2018-08-09
Information query
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