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    Stabilized fibronectin based scaffold molecules
    6.
    发明授权
    Stabilized fibronectin based scaffold molecules 有权

    公开(公告)号：US10450363B2

    公开(公告)日：2019-10-22

    申请号：US15127183

    申请日：2015-03-19

    Applicant: BRISTOL-MYERS SQUIBB COMPANY

    Inventor： Dasa Lipovsek

    IPC: C40B40/10 ,  C07K14/78 ,  A61K47/64

    Abstract: Provided herein are proteins comprising a fibronectin based scaffold (FBS) domain, e.g., 10Fn3 molecules, that bind specifically to a target, and wherein the FBS domain is linked at its C-terminus to a region consisting of PmXn, wherein P is proline, X is any amino acid and wherein n is 0 or an integer that is at least 1 and m is an integer that is at least 1, and wherein the PmXn moiety provides an enhanced property to the FBS domain, e.g., enhanced stability, relative to the protein that is not linked to the PmXn moiety.

    Fibronectin Binding Domains with Reduced Immunogenicity
    8.
    发明申请
    Fibronectin Binding Domains with Reduced Immunogenicity 有权
    具有降低的免疫原性的纤连蛋白结合结构域

    公开(公告)号：US20130245238A1

    公开(公告)日：2013-09-19

    申请号：US13757668

    申请日：2013-02-01

    Applicant: BRISTOL-MYERS SQUIBB COMPANY

    Inventor： Jonathan DAVIS ,  Dasa Lipovsek ,  Ray Camphausen

    IPC: C07K14/78 ,  C12N15/10 ,  G01N33/68

    CPC classification number: C07K14/78 ,  A61K38/00 ,  C07K14/47 ,  C07K16/241 ,  C07K16/244 ,  C07K16/28 ,  C07K16/2833 ,  C07K16/2857 ,  C07K2317/92 ,  C07K2318/20 ,  C12N15/1062 ,  C40B40/10 ,  G01N33/68 ,  G01N33/6887

    Abstract: Fibronectin type III (10Fn3) binding domains having novel designs that are associated with reduced immunogenicity are provided. The application describes alternative 10Fn3 binding domains in which certain immunogenic regions are not modified when producing a binder in order to maintain recognition as a self antigen by the host organism. The application also describes 10Fn3 binding domains in which HLA anchor regions have been destroyed thereby reducing the immunogenic contribution of the adjoining region. Also provided are 10Fn3 domains having novel combinations of modified regions that can bind to a desired target with high affinity.

    Abstract translation: 提供了具有与降低的免疫原性相关的新颖设计的纤连蛋白III型（10Fn3）结合结构域。 本申请描述了替代的10Fn3结合结构域，其中当产生粘合剂时，某些免疫原性区域不被修饰，以便由宿主生物保持识别为自身抗原。 该应用还描述了其中HLA锚定区已经被破坏的10Fn3结合结构域，从而降低相邻区域的免疫原性贡献。 还提供了10Fn3结构域，其具有可以高亲和力结合所需靶的修饰区域的新颖组合。

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