Systems and methods are disclosed for transmission and reception of an uplink grant during a gap created in radio resources assigned by a previous multiple Transmit Time Interval (multi-TTI) uplink grant in a system operating according to a Time Division Duplexing (TDD) scheme. In one embodiment, a method of operation of a radio network node in a cellular communications network is provided. The method includes transmitting a first uplink grant that assigns radio resources for a multi-TTI uplink transmission, and transmitting a second uplink grant during a gap in the radio resources assigned by the first uplink grant. In one embodiment, by utilizing the gap to transmit the second uplink grant, uplink radio resources assigned for uplink transmission can be maximized, which is particularly beneficial in high uplink traffic conditions.