Systems and methods for enhancing the availability of multi-tier applications on cloud computing platforms are disclosed. An example method comprises identifying, using a processor, dependencies among application components in a multi-tier application; generating, using the processor, an application blueprint defining the multi-tier application based on the identified dependencies; generating a remediation policy based on the identified dependencies in the application blueprint, the remediation policy comprising instructions to restore availability of the multi-tier application; detecting unavailability of the multi-tier application; identifying, using the processor, one of the application components as being responsible for the unavailability of the multi-tier application; and restarting, using the processor, the identified one of the application components based on the remediation policy to restore availability of the multi-tier application.