Invention Grant
![Salts and polymorphs of 8-fluoro-2-{4-[(methylamino)methyl]phenyl}-1,3,4,5-tetrahydro-6H-azepino[5,4,3-cd]indol-6-one](/docs/US/2019-05-07/US10278974B2/abs.jpg.600x600.jpg)
- Patent Title: Salts and polymorphs of 8-fluoro-2-{4-[(methylamino)methyl]phenyl}-1,3,4,5-tetrahydro-6H-azepino[5,4,3-cd]indol-6-one
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Application No.: US15833073Application Date: 2017-12-06
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Publication No.: US10278974B2Publication Date: 2019-05-07
- Inventor: Patricia Ann Basford , Anthony Michael Campeta , Adam Gillmore , Matthew Cameron Jones , Eleftherios Kougoulos , Suman Luthra , Robert Walton
- Applicant: Pfizer Inc.
- Applicant Address: US NY New York
- Assignee: Pfizer Inc.
- Current Assignee: Pfizer Inc.
- Current Assignee Address: US NY New York
- Agency: Cooley LLP
- Agent Ivor R. Elrifi; Heidi A. Erlacher
- Main IPC: C07D487/06
- IPC: C07D487/06 ; A61K31/55 ; C07C57/145 ; C07C309/19 ; A61K45/06
![Salts and polymorphs of 8-fluoro-2-{4-[(methylamino)methyl]phenyl}-1,3,4,5-tetrahydro-6H-azepino[5,4,3-cd]indol-6-one](/abs-image/US/2019/05/07/US10278974B2/abs.jpg.150x150.jpg)
Abstract:
The present invention relates to novel polymorphic forms of 8-fluoro-2-{4-[(methylamino)methyl]phenyl}-1,3,4,5-tetrahydro-6H-azepino[5,4,3-cd]indol-6-one, and to processes for their preparation. Such polymorphic forms may be a component of a pharmaceutical composition and may be used to treat a mammalian disease condition mediated by poly(ADP-ribose) polymerase activity including the disease condition such as cancer.
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