Invention Grant
- Patent Title: Methods for promoting hematopoietic reconstitution
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Application No.: US13836794Application Date: 2013-03-15
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Publication No.: US10278990B2Publication Date: 2019-05-07
- Inventor: Leonard I. Zon , Trista E. North , Wolfram Goessling
- Applicant: CHILDREN'S MEDICAL CENTER CORPORATION , THE GENERAL HOSPITAL CORPORATION
- Applicant Address: US MA Boston US MA Boston
- Assignee: Children's Medical Center Corporation,The General Hospital Corporation
- Current Assignee: Children's Medical Center Corporation,The General Hospital Corporation
- Current Assignee Address: US MA Boston US MA Boston
- Agency: Nixon Peabody LLP
- Main IPC: A61K35/14
- IPC: A61K35/14 ; C12N5/0789 ; A61K45/06 ; A61K35/28 ; A61K31/575 ; A61K35/50 ; A61P43/00
Abstract:
The present invention provides for compositions and methods for modulating hematopoetic stem cell populations by using HCS modulators, which are agents that either increase HSC numbers or decrease HSC numbers as desired by a particular indication. For example, HSC modulators found to increase HSC numbers include prostaglandin E2 (PGE2) and agents that stimulate the PGE2 pathway. Conversely, HSC modulators that prevent PGE2 synthesis decrease HSC numbers. HCS modulators may be used in vitro, in vivo, or ex vivo.
Public/Granted literature
- US20130209423A1 METHODS FOR PROMOTING HEMATOPOIETIC RECONSTITUTION Public/Granted day:2013-08-15
Information query
IPC分类:
