Invention Grant
![Substituted benzo[b][1,4]oxazines and pyrido[3,2-b][1,4]oxazines as modulators of tumor necrosis factor activity](/docs/US/2019-05-14/US10287299B2/abs.jpg.600x600.jpg)
- Patent Title: Substituted benzo[b][1,4]oxazines and pyrido[3,2-b][1,4]oxazines as modulators of tumor necrosis factor activity
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Application No.: US15580059Application Date: 2016-06-07
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Publication No.: US10287299B2Publication Date: 2019-05-14
- Inventor: Gareth Neil Brace , Prafulkumar Tulshibhai Chovatia , Gregory Foulkes , James Andrew Johnson , Severine Danielle Jones , Boris Kroeplien , Fabien Claude Lecomte , Pui Leng Loke , Martin Alexander Lowe , Ajay Mandal , Timothy John Norman , Christopher Francis Palmer , Yolanda Pérez-Fuertes , John Robert Porter , Donald Smyth , Giancarlo Trani , Muhammed Uddin , Zhaoning Zhu
- Applicant: UCB Biopharma SPRL
- Applicant Address: BE Brussels
- Assignee: UCB Biopharma SPRL
- Current Assignee: UCB Biopharma SPRL
- Current Assignee Address: BE Brussels
- Agency: McDonnell Boehnen Hulbert & Berghoff LLP
- Priority: GB1509893.2 20150608
- International Application: PCT/EP2016/062900 WO 20160607
- International Announcement: WO2016/198400 WO 20161215
- Main IPC: A61K31/5365
- IPC: A61K31/5365 ; C07D265/36 ; C07D498/04 ; C07D401/06 ; C07D413/06 ; A61P27/02 ; A61P3/00 ; A61P9/00 ; A61P23/00 ; A61P25/00 ; A61P29/00 ; A61P35/00 ; A61K31/423 ; A61K31/4375 ; A61K31/444 ; A61K31/4545 ; A61K31/4725 ; A61K31/473 ; A61K31/538 ; A61K31/5383 ; A61K31/55 ; C07D413/12 ; C07D413/14 ; C07D471/04 ; C07D519/00
![Substituted benzo[b][1,4]oxazines and pyrido[3,2-b][1,4]oxazines as modulators of tumor necrosis factor activity](/abs-image/US/2019/05/14/US10287299B2/abs.jpg.150x150.jpg)
Abstract:
A series of substituted 3,4-dihydro-2H-.1,4-benzoxazin-3-one derivatives, and analogs thereof, being potent modulators of human TNFa activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neuradegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders.
Public/Granted literature
- US20180134728A1 Benzoxazinone Derivatives and Analogues Thereof as Modulators of TNF Activity Public/Granted day:2018-05-17
Information query
