A electrochemical or other sensor interface circuit architecture can deliver substantial DC offset bias to an electrochemical or other sensor separately or independently from delivering a time-varying AC excitation signal, which can then be provided with higher resolution, which, in turn, can allow better resolution of the measured response signal providing the impedance characteristic of sensor condition. For example, a differential time-varying AC excitation signal for the sensor condition characteristic can be delivered separately and independently from a differential stable (e.g., DC or other) bias signal, such as by using separate digital-to-analog converters (DACs), so that providing the more stable signal does not limit the resolution and accuracy of the time-varying signal, such as by using up the dynamic range of a single DAC.