A vehicle inspection method and system are disclosed. In one aspect, the method includes acquiring a transmission image of an inspected vehicle. The method further includes acquiring a transmission image template of a vehicle model corresponding to the model of the inspected vehicle from a database. The method further includes performing registration on the transmission image of the inspected vehicle and the transmission image template. The method further includes determining a difference between a transmission image after the registration and a transmission image template after the registration, to obtain a difference area of the transmission image of the vehicle relative to the transmission image template. The method further includes processing the difference area to determine whether the vehicle carries a suspicious object or not. In some embodiments, this solution can avoid the problems of a detection loophole and a poor effect of manually determining an image in a conventional manner, and is important to assist the security inspection for small vehicles.