Invention Grant
- Patent Title: Chimeric antigen receptors targeting B-cell maturation antigen
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Application No.: US15085317Application Date: 2016-03-30
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Publication No.: US10294304B2Publication Date: 2019-05-21
- Inventor: Tracy Chia-Chien Kuo , Bijan Andre Boldajipour , Javier Fernando Chaparro Riggers , Philippe Duchateau , Roman Galetto , Alexandre Juillerat , Thomas Charles Pertel , Arvind Rajpal , Barbra Johnson Sasu , Cesar Adolfo Sommer , Julien Valton , Thomas John Van Blarcom
- Applicant: PFIZER INC.
- Applicant Address: US NY New York
- Assignee: Pfizer Inc.
- Current Assignee: Pfizer Inc.
- Current Assignee Address: US NY New York
- Agency: Cooley LLP
- Main IPC: C07K16/28
- IPC: C07K16/28 ; A61K39/395 ; C12N15/63 ; C07K14/725 ; C07K14/705 ; A61K39/00 ; A61K31/7076 ; A61K35/17 ; A61K38/00

Abstract:
The invention provides CARs (CARs) that specifically bind to BCMA (B-Cell Maturation Antigen). The invention further relates to engineered immune cells comprising such CARs, CAR-encoding nucleic acids, and methods of making such CARs, engineered immune cells, and nucleic acids. The invention further relates to therapeutic methods for use of these CARs and engineered immune cells for the treatment of a condition associated with malignant cells expressing BCMA (e.g., cancer).
Public/Granted literature
- US20160297884A1 CHIMERIC ANTIGEN RECEPTORS TARGETING B-CELL MATURATION ANTIGEN Public/Granted day:2016-10-13
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