- Patent Title: Targeted remodeling of prokaryotic genomes using CRISPR-nickases
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Application No.: US15260788Application Date: 2016-09-09
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Publication No.: US10301613B2Publication Date: 2019-05-28
- Inventor: Xiao Wang , Kylie Standage-Beier
- Applicant: Arizona Board of Regents on behalf of Arizona State University
- Applicant Address: US AZ Scottsdale
- Assignee: Arizona Board of Regents on behalf of Arizona State University
- Current Assignee: Arizona Board of Regents on behalf of Arizona State University
- Current Assignee Address: US AZ Scottsdale
- Agency: Booth Udall Fuller, PLC
- Agent Rodney J. Fuller
- Main IPC: C12N15/01
- IPC: C12N15/01 ; C12N9/22
Abstract:
The present invention relates to kits and methods of modifying the prokaryotic genome a Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)-Cas system that utilized one nicking Cas nuclease and crRNAs. The kid and methods delete or replace portions of the prokaryotic genome. In some embodiments, an entire gene or multiple genes may be deleted or replaced.
Public/Granted literature
- US20170073663A1 TARGETED REMODELING OF PROKARYOTIC GENOMES USING CRISPR-NICKASES Public/Granted day:2017-03-16
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