System (100) for calibrating particulate matter sensors includes a chamber (102) including a plurality of particulate matter sensors (104-1,104-2,104-3,104-N), a fan (110), a particulate matter source (108), an air cleaner (112), and a reference particulate matter sensor (106), a computing device (114) having a processor (118) and a memory (116) storing instructions which, when executed by the processor (118), cause the processor (118) to activate the particulate matter source (108) and the fan (110) until the reference concentration reaches a threshold, activate the air cleaner (112) responsive to the threshold being reached until the reference concentration reaches a calibration point, receive a respective determined mass concentration from each of the plurality of particulate matter sensors (104-1,104-2,104-3,104-N) at the calibration point, and calibrate each of the plurality of particulate matter sensors (104-1,104-2,104-3,104-N) based, at least in part, on a respective relationship between the reference concentration and each determined mass concentration at the calibration point. Methods and devices for calibrating particulate matter sensors are also described.