A color filter array and an image sensing device are disclosed. The color filter array includes a plurality of color cells arranged into a matrix. Each color cell has an intermediate region and a peripheral region. The peripheral region is configured around the intermediate region. The intermediate region forms a color filter object. Parts of the peripheral region form transparent objects. The transparent objects extend to edge parts of the color cells from an edge of the intermediate region. The remaining peripheral regions form the color filter objects. The color filter object is a high-refractive index material. The transparent object is a low-refractive index material. Therefore, in each color cell, the color filter objects configured in the intermediate region and the peripheral region reduce the spectral crosstalk, and the transparent objects configured in the peripheral region reduce the optical crosstalk, thereby enhancing the image quality sensed by sensor chips.