Invention Grant
- Patent Title: Isolated nucleic acid molecules encoding stabilized receptor polypeptides and uses thereof
-
Application No.: US15004375Application Date: 2016-01-22
-
Publication No.: US10308704B2Publication Date: 2019-06-04
- Inventor: Jeonghoon Sun , Lei-Ting Tony Tam , Mark Leo Michaels , Thomas Charles Boone , Rohini Deshpande , Yue-Sheng Li , Huiquan Han
- Applicant: Amgen Inc.
- Applicant Address: US CA Thousand Oaks
- Assignee: Amgen Inc.
- Current Assignee: Amgen Inc.
- Current Assignee Address: US CA Thousand Oaks
- Agent Lisa E. Alexander
- Main IPC: C07K14/71
- IPC: C07K14/71 ; C07K14/495 ; A61K38/00
Abstract:
The present invention provides stabilized activin IIB receptor polypeptides and proteins capable of binding and inhibiting the activities of activin A, myostatin, or GDF-11. The present invention also provides polynucleotides, vectors and host cells capable of producing the stabilized polypeptides and proteins. Compositions and methods for treating muscle-wasting diseases and metabolic disorders are also provided.
Public/Granted literature
- US20170183391A9 Stabilized Receptor Polypeptides and Uses Thereof Public/Granted day:2017-06-29
Information query
