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    Stabilized Receptor Polypeptides and Uses Thereof
    2.
    发明申请
    Stabilized Receptor Polypeptides and Uses Thereof 审中-公开
    稳定受体多肽及其用途

    公开(公告)号：US20160137718A1

    公开(公告)日：2016-05-19

    申请号：US15004375

    申请日：2016-01-22

    Applicant: Amgen Inc.

    Inventor： Jeonghoon Sun ,  Lei-Ting Tony Tam ,  Mark Leo Michaels ,  Thomas Charles Boone ,  Rohini Deshpande ,  Yue-Sheng Li ,  Huiquan Han

    IPC: C07K14/71

    CPC classification number: C07K14/71 ,  A61K38/00 ,  C07K14/495

    Abstract: The present invention provides stabilized activin IIB receptor polypeptides and proteins capable of binding and inhibiting the activities of activin A, myostatin, or GDF-11. The present invention also provides polynucleotides, vectors and host cells capable of producing the stabilized polypeptides and proteins. Compositions and methods for treating muscle-wasting diseases and metabolic disorders are also provided.

    Abstract translation: 本发明提供稳定的活化素IIB受体多肽和能够结合并抑制活化素A，肌生成抑制素或GDF-11的活性的蛋白质。 本发明还提供能够产生稳定的多肽和蛋白质的多核苷酸，载体和宿主细胞。 还提供了治疗肌肉消瘦疾病和代谢紊乱的组合物和方法。

    Isolated nucleic acid molecule encoding a fusion protein comprising an activin receptor
    3.
    发明授权
    Isolated nucleic acid molecule encoding a fusion protein comprising an activin receptor 有权
    分离的编码包含激活素受体的融合蛋白的核酸分子

    公开(公告)号：US09284364B2

    公开(公告)日：2016-03-15

    申请号：US14085056

    申请日：2013-11-20

    Applicant: Amgen Inc.

    Inventor： Huiquan Han ,  Keith Soo-Nyung Kwak ,  Xiaolan Zhou

    IPC: C12P21/06 ,  C12N5/02 ,  C12N15/00 ,  C07K14/71

    CPC classification number: C07K14/71 ,  C07K2319/30

    Abstract: The present invention provides novel activin IIB5 receptor polypeptides capable of binding and inhibiting the activities of activin A, myostatin, or GDF-11. The present invention also provides polynucleotides, vectors and host cells capable of producing the receptor polypeptides. Compositions and methods for treating muscle-wasting, metabolic and other disorders are also provided.

    Abstract translation: 本发明提供能够结合并抑制活化素A，肌生成抑制素或GDF-11的活性的新型激活素IIB5受体多肽。 本发明还提供能够产生受体多肽的多核苷酸，载体和宿主细胞。 还提供了用于治疗肌肉消瘦，代谢和其它疾病的组合物和方法。

    MYOSTATIN BINDING AGENTS
    8.
    发明申请
    MYOSTATIN BINDING AGENTS 审中-公开
    MYOSTATIN BINDING代理

    公开(公告)号：US20150175687A1

    公开(公告)日：2015-06-25

    申请号：US14528959

    申请日：2014-10-30

    Applicant: AMGEN INC.

    Inventor： Huiquan Han ,  Hosung Min ,  Thomas Charles Boone

    IPC: C07K16/22 ,  G01N33/74

    CPC classification number: C07K16/22 ,  A61K38/00 ,  A61K2039/505 ,  C07K14/00 ,  C07K14/475 ,  C07K2317/21 ,  C07K2317/94 ,  C07K2319/00 ,  C07K2319/30 ,  C07K2319/35 ,  C12N2710/14143 ,  G01N33/567 ,  G01N33/74 ,  G01N2333/475

    Abstract: The present invention provides binding agents comprising peptides capable of binding myostatin and inhibiting its activity. In one embodiment the binding agent comprises at least one myostatin-binding peptide attached directly or indirectly to at least one vehicle such as a polymer or an Fc domain. The binding agents of the present invention produced increased lean muscle mass when administered to animals and decreased fat to muscle ratios. Therapeutic compositions containing the binding agents of the present invention are useful for treating muscle-wasting disorders and metabolic disorders including diabetes and obesity.

    Abstract translation: 本发明提供了包含能够结合肌生成抑制素并抑制其活性的肽的结合剂。 在一个实施方案中，结合剂包含至少一种与至少一种载体如聚合物或Fc结构域直接或间接连接的肌肉生长抑制素结合肽。 本发明的粘合剂在施用于动物时产生瘦肌肉质量的降低，并且脂肪与肌肉的比例降低。 含有本发明结合剂的治疗组合物可用于治疗肌肉消瘦疾病和代谢紊乱，包括糖尿病和肥胖症。

    Anti-Activin A Antibodies and Uses Thereof
    9.
    发明申请
    Anti-Activin A Antibodies and Uses Thereof 审中-公开
    抗激素A抗体及其用途

    公开(公告)号：US20150086556A1

    公开(公告)日：2015-03-26

    申请号：US14260856

    申请日：2014-04-24

    Applicant: Amgen Inc.

    Inventor： Huiquan Han ,  Qing Chen ,  Keith Soo-Nyung Kwak ,  Xiaolan Zhou

    IPC: C07K16/22

    CPC classification number: C07K16/22 ,  A61K2039/505 ,  C07K2317/14 ,  C07K2317/21 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/76 ,  C07K2317/92

    Abstract: The disclosure provides compositions and methods relating to or derived from anti-activin A binding proteins, including antibodies. In particular embodiments, the disclosure provides fully human, humanized, and chimeric anti-activin A antibodies that bind human activin A, activin A-binding fragments and derivatives of such antibodies, and activin A-binding polypeptides comprising such fragments. Other embodiments provide nucleic acids encoding such antibodies, antibody fragments and derivatives and polypeptides, cells comprising such polynucleotides, methods of making such antibodies, antibody fragments and derivatives and polypeptides, and methods of using such antibodies, antibody fragments and derivatives and polypeptides, including methods of treating or diagnosing subjects having activin A-related disorders or conditions including cachexia related to gonadal cancer, other cancers, rheumatoid arthritis, and other diseases.

    Abstract translation: 本公开提供与抗激活素A结合蛋白（包括抗体）相关或衍生的组合物和方法。 在具体实施方案中，本公开提供了完整的人，人源化和嵌合的抗激活蛋白A抗体，其结合人激活素A，激活素A结合片段和此类抗体的衍生物，以及包含此类片段的激活素A-结合多肽。 其他实施方案提供编码此类抗体，抗体片段和衍生物和多肽的核酸，包含此类多核苷酸的细胞，制备此类抗体的方法，抗体片段和衍生物和多肽，以及使用此类抗体，抗体片段和衍生物和多肽的方法，包括方法 治疗或诊断具有激素A相关疾病或包括与性腺癌，其他癌症，类风湿性关节炎和其它疾病相关的恶病质的病症的受试者。

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