Invention Grant
- Patent Title: Polymerase variants
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Application No.: US15012317Application Date: 2016-02-01
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Publication No.: US10308918B2Publication Date: 2019-06-04
- Inventor: Aruna Ayer , Arkadiusz Bibillo , Cleoma Renetta Arnold , Charles Wayan Schwab , Eileen Thai , Ilya Lederman , Colin Alexander McGaw , Tyler O'Brien Shultz , Barbara Eckert , Shawn Suko , Mara Boenitz-Dulat , Bigna Woersdoerfer , David Daniel Wunderlich
- Applicant: Genia Technologies, Inc. , Roche Molecular Systems, Inc.
- Applicant Address: US CA Pleasanton US CA Santa Clara
- Assignee: Roche Molecular Systems, Inc.,Genia Technologies, Inc.
- Current Assignee: Roche Molecular Systems, Inc.,Genia Technologies, Inc.
- Current Assignee Address: US CA Pleasanton US CA Santa Clara
- Agency: Roche Molecular Systems, Inc.
- Main IPC: C12N9/12
- IPC: C12N9/12
Abstract:
Described herein are variant pol6 polymerase having at least having at least two substitutions, wherein at least one of the substitutions is at position S366 of SEQ ID NO: 2. The disclosed polymerases may be coupled to alpha-hemolysin nanopores, and may be used in nanopore-based sequencing apparatuses.
Public/Granted literature
- US20160222363A1 POLYMERASE VARIANTS Public/Granted day:2016-08-04
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