公开(公告)号：US20250069694A1

公开(公告)日：2025-02-27

申请号：US18722907

申请日：2022-12-22

Applicant: Roche Molecular Systems, Inc.

Inventor： Ronald Kurnik

IPC: G16B25/20 ,  G16B40/10

Abstract: Automated methods for genotyping melting curves are described. Melting curves are processed and difference matrices are compiled based on the processed matrices. The difference matrices are used to compile a cluster matrix and the cluster matrix is filtered to determine clusters that are used for genotyping the melting curves.

公开(公告)号：US20250022609A1

公开(公告)日：2025-01-16

申请号：US18902082

申请日：2024-09-30

Applicant: Roche Molecular Systems, Inc.

Inventor： Fernando Garcia-Alcalde ,  Elspeth Moira Fraser Horne ,  Carsten Magnus ,  Athanasios Siadimas ,  Antoaneta Petkova Vladimirova

IPC: G16H50/30 ,  G16H10/40 ,  G16H10/60 ,  G16H20/10 ,  G16H50/70

Abstract: Disclosed herein are techniques for facilitating a clinical decision for a patient based on identifying a group of patients having similar attributes as the patient. The group of patients can be identified using information from a predictive machine learning model that performs a clinical prediction for the patient. At least some of the attributes of the group of patients can be output to support a clinical decision. The attributes may include, for example, biography data of the patient, results of one or more laboratory tests of the patient, biopsy image data of the patient, molecular biomarkers of the patient, a tumor site of the patient, and a tumor stage of the patient.

公开(公告)号：US20240424499A1

公开(公告)日：2024-12-26

申请号：US18827465

申请日：2024-09-06

Applicant: Roche Molecular Systems, Inc.

Inventor： Lawrence Chiu ,  Reiner Hitt ,  Raphael Haag ,  Erich Caflisch ,  Nicolas Lehner

IPC: B01L9/06 ,  B65C9/02 ,  G01N35/04

Abstract: The present invention describes a secondary tube tray for use in an automated processing system, the tray comprising a base module and a secondary tube insert. Furthermore, the present invention describes a secondary tube handling module of an automated processing system for automatically processing biological sample, and a method of handling secondary tubes for use in automatically processing biological sample in an automated processing system.

公开(公告)号：USD1049419S1

公开(公告)日：2024-10-29

申请号：US29832160

申请日：2022-03-25

Applicant: Roche Molecular Systems, Inc.

Designer： Maximilian Ruhstorfer ,  Christian Thalmann ,  Adnan Wahid William Aksoy

Abstract: FIG. 1 is a top perspective view of the first embodiment of a microwell plate assembly.
FIG. 2 is a bottom perspective view of the microwell plate assembly.
FIG. 3 is a top view of the microwell plate assembly.
FIG. 4 is a bottom view of the microwell plate assembly.
FIG. 5 is a front view of the microwell plate assembly.
FIG. 6 is a back view of the microwell plate assembly.
FIG. 7 is a side view of the microwell plate assembly.
FIG. 8 is an opposite side view of the microwell plate assembly.
FIG. 9 is a top view of the microwell plate assembly;
FIG. 10 is a cross sectional view of the microwell plate assembly taken along line 10-10 of FIG. 9.
FIG. 11 is a cross sectional view of the microwell plate assembly taken along line 11-11 of FIG. 9.
FIG. 12 is a top perspective view of the second embodiment of a microwell plate assembly.
FIG. 13 is a bottom perspective view of the assembly of FIG. 12.
FIG. 14 is a top view of the microwell plate assembly of FIG. 12.
FIG. 15 is a bottom view of the microwell plate assembly of FIG. 12.
FIG. 16 is a front view of the microwell plate assembly of FIG. 12.
FIG. 17 is a back view of the microwell plate assembly of FIG. 12.
FIG. 18 is a side view of the microwell plate assembly of FIG. 12.
FIG. 19 is an opposite side view of the microwell plate assembly of FIG. 12.
FIG. 20 is a top view of the microwell plate assembly;
FIG. 21 is a cross sectional view of the microwell plate assembly of FIG. 12 taken along line 21-21 of FIG. 20.
FIG. 22 is a cross sectional view of the microwell plate assembly of FIG. 12 taken along line 22-22 of FIG. 20.
FIG. 23 is a detail cross sectional view of an individual sample well of the microwell plate assembly shown within area 23 in FIG. 21.
FIG. 24 is a detail cross sectional view of an individual sample well of the microwell plate assembly shown within area 24 in FIG. 22; and,
FIG. 25 is a detail cross sectional view of the bottom of an individual sample well of the microwell plate assembly shown within area 25 in FIG. 21.
The broken lines depict portions of the microwell plate assembly that form no part of the claimed design.

公开(公告)号：US12066311B2

公开(公告)日：2024-08-20

申请号：US17456946

申请日：2021-11-30

Applicant: Roche Molecular Systems, Inc.

Inventor： Sven Ebert ,  Michal Karol Dobrzynski ,  Paul Federer ,  Arnulf Staib ,  Lukas Schneider

IPC: G01F1/58 ,  G01F1/64

CPC classification number: G01F1/584 ,  G01F1/58 ,  G01F1/64

Abstract: The present disclosure provides for a sensor system for determining a flow rate of a fluid flow within a fluid channel comprising an elastic segment arranged next to a rigid segment, wherein a first pair of electrodes is provided at the rigid segment and a second pair of electrodes is provided at the elastic segment of the fluid channel. The system further comprises a sensor unit for detecting a capacitance of the first and second electrode pairs, and a processing unit for calculating and monitoring a distance between the electrodes of the second electrode pair based on the detected capacitance of the first electrode pair and the second electrode pair, wherein the first electrode pair is in contact with the rigid segment and the second electrode pair is in contact with the elastic segment. Moreover, a respective method for determining a flow rate of a fluid flow within a fluid channel is provided by the present disclosure, as well as a use of the sensor system.

公开(公告)号：US20240229141A1

公开(公告)日：2024-07-11

申请号：US17447978

申请日：2021-09-17

Applicant: Roche Molecular Systems, Inc.

Inventor： Rajiv Dua ,  Marcel Fontecha ,  Yan Li ,  Wei-min Liu ,  Christopher Santini ,  Lori Steiner ,  Yu Chuan Tai

IPC: C12Q1/6886

CPC classification number: C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/112 ,  C12Q2600/158 ,  C12Q2600/16

Abstract: Provided herein are methods and compositions to classify DLBCL subtypes using quantitative RT-PCR.

公开(公告)号：US12013318B2

公开(公告)日：2024-06-18

申请号：US17735466

申请日：2022-05-03

Applicant: Roche Molecular Systems, Inc.

Inventor： Carolin Bier ,  Stefan Lange ,  Pirmin Hans Loetscher

IPC: G01N1/28 ,  A01N31/02 ,  A01N31/08 ,  C12Q1/04

CPC classification number: G01N1/28 ,  A01N31/02 ,  A01N31/08 ,  C12Q1/04

Abstract: The present disclosure relates to a composition and its use for treating a sputum sample suspected to contain mycobacteria. The composition comprises thymol, a linear or branched alcohol, a chaotropic agent, a reducing agent, a detergent, and a buffer, and has a pH value between 8.5 and 10. Also disclosed is a method for treating a sputum sample suspected to contain mycobacteria.

公开(公告)号：US20240139747A1

公开(公告)日：2024-05-02

申请号：US18545923

申请日：2023-12-19

Applicant: Roche Molecular Systems, Inc.

Inventor： Lawrence Chiu ,  Ion Iordanoaia ,  Reiner Hitt ,  Vijay Namasivayam ,  Eduard Nawrocki ,  Michael Neugebauer ,  Tim Moulton ,  Sam Palmer ,  Gerd Schmieta

IPC: B01L9/06 ,  C12M3/00

CPC classification number: B01L9/06 ,  C12M23/48 ,  B01L2200/023 ,  B01L2200/028 ,  B01L2200/16 ,  B01L2300/0806

Abstract: The present invention describes a base module (100) and a tray insert (200, 300, 400) of a multipurpose tray (100) for an automated processing system, such as an analytical, pre-analytical or post-analytical processing system, as well as to a multipurpose tray comprising such base module and such tray insert, wherein the tray insert can be particularly used for holding a plurality of reagent or sample tubes to be processed in the automated processing system. The present invention further relates to a method of simplified loading/unloading of such a multipurpose tray into/from the automated processing system.

公开(公告)号：USD1024093S1

公开(公告)日：2024-04-23

申请号：US29811751

申请日：2021-10-15

Applicant: Roche Molecular Systems, Inc.

Designer： Cindy K. Barnard ,  Sambasivarao Byrapuneni ,  Diwakar Chapagain ,  Archana P. Dorge ,  Catherine M. Jeu ,  Rengaraja Kesavan ,  Kaushal D. Parekh ,  Raman Ramanathan ,  David M. Schlossman ,  Vishakha Sharma

Abstract: FIG. 1 is a front view of a first image in a sequence of a display screen or portion thereof with graphical user interface for patient timeline navigation showing our new design;
FIG. 2 is a front view of a second image thereof;
FIG. 3 is a front view of a third image thereof;
FIG. 4 is a front view of a fourth image thereof;
FIG. 5 is a front view of a fifth image thereof;
FIG. 6 is a front view of a sixth image thereof; and,
FIG. 7 is a front view of a seventh image thereof.
The outermost broken line rectangular indicates a boundary of a display screen or a portion thereof and forms no part of the claimed design. The broken lined text, patterns, and characters form no part of the claimed design. The appearance of the animated images sequentially transition from FIG. 1 to FIG. 7. The process or period in which one image transitions to another forms no part of the claimed design.

公开(公告)号：US20240110162A1

公开(公告)日：2024-04-04

申请号：US18219045

申请日：2023-07-06

Applicant: Roche Molecular Systems, Inc.

Inventor： Feruz Kurbanov

IPC: C12N9/12 ,  C12Q1/6844

CPC classification number: C12N9/1252 ,  C12Q1/6844 ,  C12Y207/07007

Abstract: Disclosed are DNA polymerases having increased 5′-3′ strand displacement activity and substantially reduced 5′-3′ exonuclease and endonuclease activity relative to a corresponding, unmodified polymerase. The polymerases are useful in a variety of disclosed primer extension methods. Also disclosed are related compositions, including recombinant nucleic acids, vectors, and host cells, which are useful, e.g., for production of the DNA polymerases.