A fluid quantification instrument is provided according to the invention. The fluid quantification instrument includes one or more sensor probes and meter electronics in communication with the one or more sensor probes. The meter electronics are configured to receive one or more raw fluid measurements from the one or more sensor probes, process the one or more raw fluid measurements using a predictive system model to produce one or more optimized fluid measurements, and determine one or more fluid quantifications using at least the one or more optimized fluid measurements.