- 专利标题： Modulation of complement-dependent cytotoxicity through modifications of the C-terminus of antibody heavy chains
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申请号： US14130580申请日： 2012-07-06
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公开(公告)号： US10323081B2公开(公告)日： 2019-06-18
- 发明人: Paul Parren , Patrick Van Berkel , Ewald T. J. Van Den Bremer
- 申请人： Paul Parren , Patrick Van Berkel , Ewald T. J. Van Den Bremer
- 申请人地址： DK Copenhagen V
- 专利权人： GENMAG A/S
- 当前专利权人： GENMAG A/S
- 当前专利权人地址： DK Copenhagen V
- 代理机构： Nelson Mullins Riley & Scarborough LLP
- 代理商 Jane E. Remillard, Esq.; Christopher L. Frank
- 优先权： DK201100518 20110706
- 国际申请： PCT/EP2012/063338 WO 20120706
- 国际公布： WO2013/004841 WO 20130110
- 主分类号： C07K16/18
- IPC分类号： C07K16/18 ; C07K16/00 ; G01N33/50 ; G01N33/68
摘要：
Provided are antibody variants having decreased or increased ability to mediate complement-dependent cytotoxicity (CDC) due to the presence or absence of C-terminal lysines of their heavy chains. Also provided are methods of generating such antibodies, as well as nucleotide constructs and host cells suitable for the production of such antibodies.
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