A node controller-based request responding method and node controller, where the method includes receiving, by a first node controller, a first packet, acquiring an information directory, and querying, in the information directory, whether a memory address requested by the first packet is occupied by a second node controller, and when the memory address requested by the first packet is occupied by the second node controller, querying node presence information to determine whether the second node controller exists, and when it is determined that the second node controller does not exist, generating and sending an invalid response packet.