A high-performance computing system, method, and storage medium manage accesses to multiple memory modules of a computing node, the modules having different access latencies. The node allocates its resources into pools according to pre-determined memory access criteria. When another computing node requests a memory access, the node determines whether the request satisfies any of the criteria. If so, the associated pool of resources is selected for servicing the request; if not, a default pool is selected. The node then services the request if the pool of resources is sufficient. Otherwise, various error handling processes are performed. Each memory access criterion may relate to a memory address range assigned to a memory module, a type of request, a relationship between the nodes, a configuration of the requesting node, or a combination of these.