A multi-chamber tire, comprising an outer layer portion and an flexible ring body in an annular fashion; the outer layer portion is arranged on the external side of the flexible ring body; the flexible ring portion is provided with chambers arranged around the flexible ring portion; the chambers are provided with a plurality of partitioned gussets; each of the partitioned gussets is arranged around the flexible ring body and extends along the axial and radial directions, and the plurality of partitioned gussets are arranged around the flexible ring body alternately, dividing the chambers into a plurality of isolating chambers isolated from each other.