Embodiments of a user equipment (UE), an access node and a slice-based handover method are provided. In an embodiment of the method, a service request is sent from a UE to an access node. Multiple candidate slice instances provided by cells of the access node and its neighbor nodes that support the service request are then selected. Various measurement objects with respect to each candidate slice instance are measured and a measurement report is sent to the access node by the UE. A target cell with at least one slice instance that supports the service request is decided from the candidate slice instances according to the measurement report. Finally, a control command is sent to the UE by the access node to configure a connection between the UE and the target cell.