Invention Grant
- Patent Title: Phosphohistidine mimetics and antibodies to same
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Application No.: US15026670Application Date: 2014-10-02
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Publication No.: US10351581B2Publication Date: 2019-07-16
- Inventor: Tom W. Muir , Rob C. Oslund , Jung-Min Kee
- Applicant: The Trustees of Princeton University
- Applicant Address: US NJ Princeton
- Assignee: THE TRUSTEES OF PRINCETON UNIVERSITY
- Current Assignee: THE TRUSTEES OF PRINCETON UNIVERSITY
- Current Assignee Address: US NJ Princeton
- Agency: Meagher Emanuel Laks Goldberg & Liao, LLP
- International Application: PCT/US2014/058758 WO 20141002
- International Announcement: WO2015/051079 WO 20150409
- Main IPC: C07F9/6503
- IPC: C07F9/6503 ; C07K16/44 ; G01N33/53

Abstract:
Provided are phosphonopyrazole-based phosphohistidine analogs that are useful as haptens for the preparation of immunogens, immunogens that include these haptens linked to carrier molecules, antibodies thereto and uses of these antibodies, haptens, immunogens and phosphohistidine analogs. The invention is based in part on new pHis analogs that are chemically stable and which have been used as haptens and immunogens to generate specific anti-pHis antibodies that bind with high affinity and specificity.
Public/Granted literature
- US20160311838A1 PHOSPHOHISTIDINE MIMETICS AND ANTIBODIES TO SAME Public/Granted day:2016-10-27
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