Invention Grant
- Patent Title: Treatment of cancer using anti-CD19 Chimeric Antigen Receptor
-
Application No.: US14680860Application Date: 2015-04-07
-
Publication No.: US10357514B2Publication Date: 2019-07-23
- Inventor: Carl H. June , David L. Porter , Marcela Maus , Mariusz Wasik , Saar Gill , Joseph Fraietta , Marco Ruella , John Byrd , Jason Dubovsky , Amy Johnson , Natarajan Muthusamy , Saad Kenderian , Joan Mannick , David Glass , Leon Murphy , Jennifer Brogdon , William Raj Sellers
- Applicant: The Trustees of the University of Pennsylvania , Novartis AG
- Applicant Address: US PA Philadelphia CH Basel
- Assignee: The Trustees of the University of Pennsylvania,Novartis AG
- Current Assignee: The Trustees of the University of Pennsylvania,Novartis AG
- Current Assignee Address: US PA Philadelphia CH Basel
- Agency: Lando & Anastasi, LLP
- Main IPC: A61K35/17
- IPC: A61K35/17 ; A61K39/395 ; A61K31/519 ; A61K45/06 ; C07K14/725 ; A61K31/436 ; A61K31/53 ; C12N5/0783 ; C07K16/28 ; A61K39/00
Abstract:
The invention provides compositions and methods for treating diseases associated with expression of CD19, e.g., by administering a recombinant T cell comprising the CD19 CAR as described herein, in combination with a kinase inhibitor, e.g., a kinase inhibitor described herein. The invention also provides kits and compositions described herein.
Public/Granted literature
- US20150283178A1 TREATMENT OF CANCER USING ANTI-CD19 CHIMERIC ANTIGEN RECEPTOR Public/Granted day:2015-10-08
Information query
IPC分类:
