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公开(公告)号：US20240252538A1
公开(公告)日：2024-08-01
申请号：US18529915
申请日：2023-12-05
发明人： Barbara Brannetti , Jennifer Brogdon , Boris Engels , Brian Walter Granda , Lu Huang , Ming Lei , Na Li , Jimin Zhang , Carla Patricia Pinto Guimaraes , Saar Gill , Marco Ruella , Regina M. Young
CPC分类号： A61K35/17 , A61K38/1774 , A61P35/00 , C07K16/2803 , C07K16/2887 , C07K16/2896 , C12N15/85 , A61K2039/505 , C07K2317/24 , C07K2317/31 , C07K2317/622 , C07K2319/03 , C07K2319/33
摘要： The invention provides compositions and methods for treating diseases associated with expression of CD20 or CD22. The invention also relates to chimeric antigen receptor (CAR) specific to CD20 or CD22, vectors encoding the same, and recombinant T or natural killer (NK) cells comprising the CD20 CAR or CD22 CAR. The invention also includes methods of administering a genetically modified T cell or NK cell expressing a CAR that comprises a CD20 or CD22 binding domain.
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2.发明申请公开(公告)号：US20190292238A1
公开(公告)日：2019-09-26
申请号：US16256731
申请日：2019-01-24
发明人： Hans Bitter , Jennifer Mary Bordeaux , Barbara Brannetti , Jennifer Brogdon , Naveen Kumar Dakappagari , Saar Gill , Steven Highfill , Lu Huang , Carl H. June , Ju Young Kim , Ming Lei , Na Li , Andreas Loew , Elena Orlando , Marco Ruella , Thai Tran , Jimin Zhang , Li Zhou
IPC分类号： C07K14/705 , A61K39/00 , C07K16/28 , C07K14/725 , A61K45/06
摘要： The invention provides compositions and methods for treating diseases associated with expression of CD19, e.g., by administering a recombinant T cell comprising the CD19 CAR as described herein, in combination with one or more B-cell inhibitors, e.g., inhibitors of one or more of CD10, CD20, CD22, CD34, CD123, FLT-3, ROR1, CD79b, CD179b, or CD79a. The disclosure additionally features novel antigen binding domains and CAR molecules directed to CD20 and CD22, and uses, e.g., as monotherapies or in combination therapies. The invention also provides kits and compositions described herein.
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公开(公告)号：US20180140602A1
公开(公告)日：2018-05-24
申请号：US15564463
申请日：2016-04-07
申请人： Daniela Angst , John Byrd , Jason Dubovsky , Joseph A. Fraietta , Francois Gessier , Saar Gill , Amy Johnson , Carl H. June , Marcela Maus , Natarajan Muthusamy , David L. Porter , Marco Ruella , Anna Vulpetti , Mariusz Wasik , Novartis AG , The Trustees of the University of Pennsylvania
发明人： Daniela Angst , John Byrd , Jason Dubovsky , Joseph A. Fraietta , Francois Gessier , Saar Gill , Amy Johnson , Carl H. June , Marcela Maus , Natarajan Muthusamy , David L. Porter , Marco Ruella , Anna Vulpetti , Mariusz Wasik
IPC分类号： A61K31/505 , A61K35/17 , C07K16/28 , A61K31/506 , C07K16/30 , A61P35/00 , A61P35/02
CPC分类号： A61K31/505 , A61K31/506 , A61K35/17 , A61K45/06 , A61K2035/124 , A61K2039/505 , A61K2039/545 , A61P35/00 , A61P35/02 , C07K16/2803 , C07K16/30 , C07K2317/24 , C07K2317/53 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2319/02 , C07K2319/03 , C12N5/0636 , A61K2300/00
摘要： The invention provides compositions and methods for treating diseases associated with expression of CD19, e.g., by administering a recombinant T cell comprising the CD19 CAR as described herein, in combination with a BTK inhibitor, e.g., an amino pyrimidine derivative described herein. The invention also provides kits and compositions described herein.
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4.再颁专利公开(公告)号：USRE49847E1
公开(公告)日：2024-02-27
申请号：US17569389
申请日：2022-01-05
发明人： Barbara Brannetti , Jennifer Brogdon , Boris Engels , Brian Granda , Lu Huang , Ming Lei , Na Li , Jimin Zhang , Carla Guimaraes , Saar Gill , Marco Ruella , Regina M. Young
CPC分类号： A61K35/17 , A61K38/1774 , A61P35/00 , C07K16/2803 , C07K16/2887 , C07K16/2896 , C12N15/85 , A61K2039/505 , C07K2317/24 , C07K2317/31 , C07K2317/622 , C07K2319/03 , C07K2319/33
摘要： The invention provides compositions and methods for treating diseases associated with expression of CD20 or CD22. The invention also relates to chimeric antigen receptor (CAR) specific to CD20 or CD22, vectors encoding the same, and recombinant T or natural killer (NK) cells comprising the CD20 CAR or CD22 CAR. The invention also includes methods of administering a genetically modified T cell or NK cell expressing a CAR that comprises a CD20 or CD22 binding domain.
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公开(公告)号：US20230220090A1
公开(公告)日：2023-07-13
申请号：US18148807
申请日：2022-12-30
发明人： Jennifer Brogdon , Saar Gill , David Glass , Saad Kenderian , Andreas Loew , Joan Mannick , Michael C. Milone , Leon Murphy , David L. Porter , Marco Ruella , Yongqiang Wang , Qilong Wu , Jiquan Zhang
IPC分类号： C07K16/28 , A61K39/00 , C07K16/24 , C12N5/0783
CPC分类号： C07K16/2866 , A61K39/001119 , C07K16/244 , C12N5/0636 , C07K2317/622 , C07K2319/33 , A61K2039/505 , A61K2039/5156 , C07K2317/76 , C07K2317/73 , C07K2319/03 , A61K2039/507 , C07K2317/24
摘要： The invention provides compositions and methods for treating diseases associated with expression of CD123. The invention also relates to chimeric antigen receptor (CAR) specific to CD123, vectors encoding the same, and recombinant cells comprising the CD123 CAR. The invention also includes methods of administering a genetically modified cell expressing a CAR that comprises a CD123 binding domain.
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6.发明授权公开(公告)号：US11026976B2
公开(公告)日：2021-06-08
申请号：US16664223
申请日：2019-10-25
发明人： Barbara Brannetti , Jennifer Brogdon , Boris Engels , Brian Walter Granda , Lu Huang , Ming Lei , Na Li , Jimin Zhang , Carla Guimaraes , Saar Gill , Marco Ruella , Regina M. Young
摘要： The invention provides compositions and methods for treating diseases associated with expression of CD20 or CD22. The invention also relates to chimeric antigen receptor (CAR) specific to CD20 or CD22, vectors encoding the same, and recombinant T or natural killer (NK) cells comprising the CD20 CAR or CD22 CAR. The invention also includes methods of administering a genetically modified T cell or NK cell expressing a CAR that comprises a CD20 or CD22 binding domain.
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公开(公告)号：US10253086B2
公开(公告)日：2019-04-09
申请号：US15094674
申请日：2016-04-08
发明人： Hans Bitter , Jennifer Mary Bordeaux , Barbara Brannetti , Jennifer Brogdon , Naveen Kumar Dakappagari , Saar Gill , Steven Highfill , Lu Huang , Carl H. June , Ju Young Kim , Ming Lei , Na Li , Andreas Loew , Elena Orlando , Marco Ruella , Thai Tran , Jimin Zhang , Li Zhou
IPC分类号： A61K38/00 , A61K39/00 , A61K45/06 , C07K16/28 , C07K14/705 , C07K14/725
摘要： The invention provides compositions and methods for treating diseases associated with expression of CD19, e.g., by administering a recombinant T cell comprising the CD19 CAR as described herein, in combination with one or more B-cell inhibitors, e.g., inhibitors of one or more of CD10, CD20, CD22, CD34, CD123, FLT-3, ROR1, CD79b, CD179b, or CD79a. The disclosure additionally features novel antigen binding domains and CAR molecules directed to CD20 and CD22, and uses, e.g., as monotherapies or in combination therapies. The invention also provides kits and compositions described herein.
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8.发明申请公开(公告)号：US20170183415A1
公开(公告)日：2017-06-29
申请号：US15400096
申请日：2017-01-06
发明人： Jennifer Brogdon , Saar Gill , Carl H. June , Michael D. Kalos , Andreas Loew , John Scholler
IPC分类号： C07K16/28 , A61K35/17 , A61K38/17 , C07K14/705 , A61K39/395 , A61K35/28 , C07K14/725
CPC分类号： C07K16/2866 , A61K35/17 , A61K35/28 , A61K38/1774 , A61K39/3955 , A61K2039/505 , A61K2039/507 , A61K2039/5158 , C07K14/7051 , C07K14/70517 , C07K16/2803 , C07K2317/24 , C07K2317/53 , C07K2317/622 , C07K2317/73 , C07K2319/00 , C07K2319/30 , C07K2319/33
摘要： The invention provides compositions and methods for treating leukemia, for example, acute myeloid leukemia (AML) and B-cell acute lymphoid leukemia (B-ALL). The invention also relates to at least one chimeric antigen receptor (CAR) specific to CD123, vectors comprising the same, and recombinant T cells comprising the CD123 CAR. The invention also includes methods of administering a genetically modified T cell expressing a CAR that comprises a CD123 binding domain. The invention also includes methods of bone marrow ablation for use in treatments necessitating bone marrow reconditioning or transplant.
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公开(公告)号：US20210002377A1
公开(公告)日：2021-01-07
申请号：US16884867
申请日：2020-05-27
发明人： Jennifer Brogdon , Saar Gill , David Jonathan Glass , Saad Kenderian , Andreas Loew , Joan Mannick , Michael C. Milone , Leon Murphy , David L. Porter , Marco Ruella , Yongqiang Wang , Qilong Wu , Jiquan Zhang
IPC分类号： C07K16/28 , A61K39/00 , C07K16/24 , C12N5/0783
摘要： The invention provides compositions and methods for treating diseases associated with expression of CD123. The invention also relates to chimeric antigen receptor (CAR) specific to CD123, vectors encoding the same, and recombinant cells comprising the CD123 CAR. The invention also includes methods of administering a genetically modified cell expressing a CAR that comprises a CD123 binding domain.
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公开(公告)号：US20190388471A1
公开(公告)日：2019-12-26
申请号：US16435257
申请日：2019-06-07
发明人： Carl H. June , David L. Porter , Marcela Maus , Mariusz Wasik , Saar Gill , Joseph A. Fraietta , Marco Ruella , John Byrd , Jason Dubovsky , Amy Johnson , Natarajan Muthusamy , Saad Kenderian , Joan Mannick , David Jonathan Glass , Leon Murphy , Jennifer Brogdon , William Raj Sellers
IPC分类号： A61K35/17 , A61K39/395 , A61K31/519 , A61K45/06 , C07K14/725 , A61K31/436 , A61K31/53 , C12N5/0783 , C07K16/28
摘要： The invention provides compositions and methods for treating diseases associated with expression of CD19, e.g., by administering a recombinant T cell comprising the CD19 CAR as described herein, in combination with a kinase inhibitor, e.g., a kinase inhibitor described herein. The invention also provides kits and compositions described herein.
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