![Method for preparing efficiently synthetic sitafloxacin intermediate (7S)-5-azaspiro[2.4]heptane-7-yl tert-butyl carbamate](/docs/US/2019-07-23/US10358417B2/abs.jpg.600x600.jpg)
- 专利标题： Method for preparing efficiently synthetic sitafloxacin intermediate (7S)-5-azaspiro[2.4]heptane-7-yl tert-butyl carbamate
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申请号： US16062846申请日： 2017-04-25
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公开(公告)号： US10358417B2公开(公告)日： 2019-07-23
- 发明人: Yingjie Lai , Dabing Ye , Fengrui Lang , Xiangtian Long
- 申请人： Chen-Stone (Guangzhou) Co., Ltd.
- 申请人地址： CN Guangdong
- 专利权人： Chen-Stone (Guangzhou) Co., Ltd.
- 当前专利权人： Chen-Stone (Guangzhou) Co., Ltd.
- 当前专利权人地址： CN Guangdong
- 代理机构： Warner Norcross + Judd LLP
- 优先权： CN201610301567 20160506
- 国际申请： PCT/CN2017/081893 WO 20170425
- 国际公布： WO2017/190609 WO 20171109
- 主分类号： C07D209/54
- IPC分类号： C07D209/54
![Method for preparing efficiently synthetic sitafloxacin intermediate (7S)-5-azaspiro[2.4]heptane-7-yl tert-butyl carbamate](/abs-image/US/2019/07/23/US10358417B2/abs.jpg.150x150.jpg)
摘要：
The present invention discloses a preparation method for efficient synthesis of sitafloxacin intermediate (7S)-5-azaspiro[2.4]heptane-7-yl-tert-butyl carbamate, comprising the following steps: reacting to obtain reacting to obtain reacting to obtain and reacting to obtain In the present invention, a single compound with a relatively high ee value can be obtained, the unnecessary waste of materials is avoided, the yield is significantly improved, the operation is simple, the industrial scale-up is easy, and the production cost is reduced.