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公开(公告)号:US10358417B2
公开(公告)日:2019-07-23
申请号:US16062846
申请日:2017-04-25
发明人: Yingjie Lai , Dabing Ye , Fengrui Lang , Xiangtian Long
IPC分类号: C07D209/54
摘要: The present invention discloses a preparation method for efficient synthesis of sitafloxacin intermediate (7S)-5-azaspiro[2.4]heptane-7-yl-tert-butyl carbamate, comprising the following steps: reacting to obtain reacting to obtain reacting to obtain and reacting to obtain In the present invention, a single compound with a relatively high ee value can be obtained, the unnecessary waste of materials is avoided, the yield is significantly improved, the operation is simple, the industrial scale-up is easy, and the production cost is reduced.
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2.
公开(公告)号:US20180370914A1
公开(公告)日:2018-12-27
申请号:US16062846
申请日:2017-04-25
发明人: Yingjie Lai , Dabing Ye , Fengrui Lang , Xiangtian Long
IPC分类号: C07D209/54
CPC分类号: C07D209/54 , Y02P20/55
摘要: The present invention discloses a preparation method for efficient synthesis of sitafloxacin intermediate (7S)-5-azaspiro[2.4]heptane-7-yl-tert-butyl carbamate, comprising the following steps: reacting to obtain reacting to obtain reacting to obtain and reacting to obtain In the present invention, a single compound with a relatively high ee value can be obtained, the unnecessary waste of materials is avoided, the yield is significantly improved, the operation is simple, the industrial scale-up is easy, and the production cost is reduced.
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