Disclosed is a hydraulic drive system capable of improving the fuel efficiency of a work machine by reducing the pressure loss and drag loss of a hydraulic pump. There are provided an electric motor M; a third pump P3 driven by the electric motor; a third pump hydraulic line L3 to which the delivered hydraulic fluid from the third pump is supplied; a third directional control valve V4 provided in the third pump hydraulic line, switch-operated by an arm operation device 19, and controlling the flow rate of the hydraulic fluid supplied to the arm cylinder 8 from the third hydraulic pump; and a controller 18 drive-controlling the electric motor, wherein the controller drives the third pump by the electric motor when a swing/arm combined operation is detected by pilot pressure sensors S6, S7, S10, S11.